ID   XPO4_CHICK              Reviewed;        1154 AA.
AC   Q5ZMR9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Exportin-4;
GN   Name=XPO4; ORFNames=RCJMB04_1f17;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC       substrate specificity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AJ719315; CAG30974.1; -; mRNA.
DR   RefSeq; NP_001012965.1; NM_001012947.2.
DR   AlphaFoldDB; Q5ZMR9; -.
DR   SMR; Q5ZMR9; -.
DR   STRING; 9031.ENSGALP00000027623; -.
DR   PaxDb; Q5ZMR9; -.
DR   PRIDE; Q5ZMR9; -.
DR   GeneID; 428081; -.
DR   KEGG; gga:428081; -.
DR   CTD; 64328; -.
DR   VEuPathDB; HostDB:geneid_428081; -.
DR   eggNOG; KOG4541; Eukaryota.
DR   InParanoid; Q5ZMR9; -.
DR   OrthoDB; 106880at2759; -.
DR   PhylomeDB; Q5ZMR9; -.
DR   PRO; PR:Q5ZMR9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR044189; XPO4/7-like.
DR   PANTHER; PTHR12596; PTHR12596; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1154
FT                   /note="Exportin-4"
FT                   /id="PRO_0000237670"
SQ   SEQUENCE   1154 AA;  130317 MW;  4FA6B885AD14A62C CRC64;
     MMAAAAAAGG APEVIAQLEN AAKVLMAPPS MVNNEQRQHA EHIFLSFRKS KSPFAVCKHI
     LETSKVDYVL FQAATAIMEA VVREWILLEK TSIESLRTFL LTYVLQRPNL QKYVREQILL
     AVAVIVKRGS LDKSIDCKSI FHEVSQLISS GNPTVQTLAC SILTALLSEF SSSSKTSNIG
     LSMEFHGNCK RIFQEDDLRQ IFMLTVEVLQ EFRRRENLNA QMSSVFQRYL ALANQVLSWN
     FLPPNLGRHY IAMFESSQNV MLKPTESWRE TLLDSRVMEL FFTVHRKIRE DTDMAQDSLQ
     CLAQLASLHG SVFPDEGSQV DYLAHFIEGL LNTISGIEIE DSEAVGISSI ISNLITVFPR
     NILTAIPNEL FSSFVNCLAH LTCSFGRSAA LEEVLDKDDM VYMEAYDKLL ESWLTLVQDD
     KHFHKGFFTQ HAVQVFNSYI QCHLAAPDGT RNLTANGVAS REEEEISELQ EDDRDQFCDQ
     LASVGMLGRI AAEHCIPLLT SLLEDRVTRL HGQLQRHQQQ LLASPASGSI DNKVLDDLYE
     DIHWLILVTG YLLANDTQGE TPLIPPEVME YSIKHSTEVD INTTLQILGS PGEKASSIPG
     YNRTDSVIRL LSAILRVSEV ESRAIRANLT HLLSPQMGKD IVWFLKRWAK TYLLADEKLY
     DQISLPFSTA FGADTEGSQW IVGYLLEKVI SNLAVWSSEQ DLANDTVQLL VTLVERRERA
     NLVIQCENWW NLAKQFARRS PPLHYLSSSV QRTLMKALVL GGFAHMDTEM KQQYWTEVLQ
     PLQQRFLNVI NQENFQQICQ EEEVKQEITA TLEALCGIAE ATQIDNVAIL FNFLMDFLNN
     CIGLMEVYKN TPETVNLIIE VFVEVAHKQI CYLGEAKAMN LYEACLTLLQ VYSKNNLGRQ
     RIDVTAEEDQ YQDLLLIMEL LTNLLSKEFI DFSDTDEVFR GHEPGQATNR TVSAADVVLY
     GVNLVLPLMS QDLLKFPSLC NQYYKLITFI CEIFPEKIPQ LPEDLFKSLM YSLELGMSSM
     SSEVCQLCLE AVTPLAEQCA KAQETDSALF LATRHFLKMV FDMLVLQKHN TEMTTAAGEA
     FYTLVCLHQA EYSELVETLL STQQDPVIYQ RLADAFNKLT ASSTPPTLDR KQKMAFLKSL
     EEFMANVGGL LCVK