ID   XPO4_DANRE              Reviewed;        1150 AA.
AC   Q802D3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Exportin-4;
GN   Name=xpo4; ORFNames=zgc:55678;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC       substrate specificity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC048882; AAH48882.1; -; mRNA.
DR   RefSeq; NP_997839.1; NM_212674.2.
DR   AlphaFoldDB; Q802D3; -.
DR   SMR; Q802D3; -.
DR   STRING; 7955.ENSDARP00000005176; -.
DR   PaxDb; Q802D3; -.
DR   PeptideAtlas; Q802D3; -.
DR   GeneID; 324342; -.
DR   KEGG; dre:324342; -.
DR   CTD; 64328; -.
DR   ZFIN; ZDB-GENE-030131-3062; xpo4.
DR   eggNOG; KOG4541; Eukaryota.
DR   InParanoid; Q802D3; -.
DR   OrthoDB; 106880at2759; -.
DR   PhylomeDB; Q802D3; -.
DR   PRO; PR:Q802D3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR044189; XPO4/7-like.
DR   PANTHER; PTHR12596; PTHR12596; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1150
FT                   /note="Exportin-4"
FT                   /id="PRO_0000237671"
SQ   SEQUENCE   1150 AA;  129227 MW;  C6CBF583D4108EB7 CRC64;
     MMAAVGAPEV ISQLESAAKV LMAPPSMVST EQRQHAEHIF LSFRKSKSPF AVCKHILETS
     KVDYVLFQAA TAIMEAVVRE WILLEKNSIE SLRTFLLTYV LQRPNLQKYV REQILLAVAV
     IVKRGSLDKS INCKSIFLEV SQLISSGNPT VQTLACSILT ALLSEFSSSN KTSNIGLSME
     FHGSCKRIFQ EDDLRQIFML TMEVLQEFSR RENLNAQMSC VFQRYLALAN QVLSWNFLPP
     NLGRHYIAMF EATPNVMLKP TESWRESLLD HRVMDLFFTV HRKIREDSDM AQDSLQCLAQ
     LASMQGPIFP DESAQVTYLA HLVEGLLNMI NGIEIEDSEA VGISNIISNL ISTFSRSVLT
     ALPNVLFASF INCLTLLTCS FGRSAALEEV LDKDDMVYME AYDKLLESWL TLVQEDEHFP
     RGCFVQPAVQ VFNSYIQCHL AAPDGTRNLT ANGVASHEEE EINELQEDDR ELFSDQLASI
     GMLGRIAADH CIPLLTGLLE DRVTRLHGQL QRHQQHLMAA ADPDTVDRKV LDDLYEDIHW
     LILVSGYLLA DVPQGETPLI PSEVMEYSIK HSTEVDINTT LQLLGSPGEK ATSIPGCNRT
     DSVIRLLSAV LRTSEVESRA TRASLTQLLS PQMGKDIVWF LRRWAKTYLL VDEKLYGQIS
     MPLSTAFGAD TEGAQWIVGY LLEKVINNLS VWSSEPELAN DTVELLVTLV EKRERANIVV
     QCENWWSLAK QFASRSPPLH MLSSTVQRTL MKALVLGGFA HMDSDTKQQY WAEVLHPLQQ
     RFLNLINQEN FAQICQEVAV KQEIVATLEA LCGIAEATQI DNVASLFSFL MDFLSSCIGL
     MEVYRNSPET VNLIIEVFVE VAHKQICYLG ETKSMKLYEV CLTLLQVYSK NNLGRKRLDV
     AAEEDQYQDL LLIMELLTNL LSKEFIDFSD TDEVLRGQEQ SSGAGRAVSA ADVVLYGVNI
     VLPLMSQDLL KFPSLCNQYY KLITFICEIF PEKIPQLPEE LFKSLMCSLE LGMTSMSSEI
     SQLCLEALSP LAEQCAKTQE KDTPLFIATR HFLKLVFDML VLQKHNTEMT VAAGEALYTL
     VCLHQAEYSE LVETLLSNQR DALIYQRLAD AFNNLTASST PPTMDRKQKV AFLKSLEEFV
     ANVGGLLCVK