XPO4_DICDI
ID XPO4_DICDI Reviewed; 1133 AA.
AC Q54UP5;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Exportin-4;
DE Short=Exp4;
GN Name=xpo4; ORFNames=DDB_G0280907;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the nuclear export of proteins (cargos). In the
CC nucleus binds cooperatively to its cargo and to the GTPase Ran in its
CC active GTP-bound form. Docking of this trimeric complex to the nuclear
CC pore complex (NPC) is mediated through binding to nucleoporins. Upon
CC transit of a nuclear export complex into the cytoplasm, disassembling
CC of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of
CC the cargo from the export receptor. Xpo4 then return to the nuclear
CC compartment and mediate another round of transport. The directionality
CC of nuclear export is thought to be conferred by an asymmetric
CC distribution of the GTP- and GDP-bound forms of Ran between the
CC cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9C0E2}.
CC -!- SUBUNIT: Interacts with Ran and cargo proteins in a GTP-dependent
CC manner. {ECO:0000250|UniProtKB:Q9C0E2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9C0E2}. Nucleus
CC {ECO:0000250|UniProtKB:Q9C0E2}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000250|UniProtKB:Q9C0E2}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AAFI02000039; EAL66995.1; -; Genomic_DNA.
DR RefSeq; XP_640976.1; XM_635884.1.
DR AlphaFoldDB; Q54UP5; -.
DR SMR; Q54UP5; -.
DR STRING; 44689.DDB0237580; -.
DR PaxDb; Q54UP5; -.
DR EnsemblProtists; EAL66995; EAL66995; DDB_G0280907.
DR GeneID; 8622780; -.
DR KEGG; ddi:DDB_G0280907; -.
DR dictyBase; DDB_G0280907; xpo4.
DR eggNOG; KOG4541; Eukaryota.
DR HOGENOM; CLU_005818_0_0_1; -.
DR InParanoid; Q54UP5; -.
DR OMA; KSISCKS; -.
DR PhylomeDB; Q54UP5; -.
DR PRO; PR:Q54UP5; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; PTHR12596; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..1133
FT /note="Exportin-4"
FT /id="PRO_0000328538"
SQ SEQUENCE 1133 AA; 130185 MW; 84422A470E155546 CRC64;
MEIEFIQNLE KFCIGLQSNK SNERETSEQS ILTLMKTPQP YKLCFNLLSK SNLTIAHFYG
LLMIRDSAIR EWAALDSQTK IMIIETLFQY IENMNSMNFL NYATKGQSFN TLGVIIKRSW
LDNEKYEIGK GQMELNQIVM DRVYQYIDSG SPDRIEISIK IIGSLIIEFS SSSKAAHIQL
SWEFHQKCLI TFQNLHLQPI FRKVLELLQQ FKDHIQQVPS RLTDQSFLQI LYTSVKVFTD
ILDWRFLESG SSVLAYITSF SGGRTNLKPT IEWISLFTPS QSGGGISPIV SLVFGLYQLV
EKVEKIPNLL RHAMSQLCGL QGPIIKDQKI KNQYLSEVLT FTNKLIEKSI TTRNWNEMED
ISNIIYKFCN TYKFSGIACL PNQIVIPFLQ YTTQFVLSSL NLMKIWAKHG EEELEEEFEN
DCFDILLRSF VSLISDAEML INRKRVDQLE NFKEQYQVLK QCTSQIYQNY IQSRLELSEI
EINKSNEELE PTCKSRGGIG GAEDEIDEDK KKYDEQLRSV AYIGRLNPGQ SLELLKNEIN
RVINSLKERV SDPILFESLH WLLIFAGHLI FDAENKTPSA IPNAIEDYTF EQCKLTPASQ
VDGVIDLCNA VFRFHMEYEN PLLNNGKMDT ISPLVSQTSL WFTSGWSLVY LLPSSVFNVQ
ISPKIIEAYG TEQPLLSITD YFINKILLNL KCWSGDLDVL KATSNLLNSF TLNKELCKYL
IRSPNWSRLF FLEGISLLPP SVYGQLFKAF SRVVFSFPLS TRREYFIQLV KTLVEQMDGV
LGRADFTKIS QEAKIKENIY ILLEKLNGIV SVSESEYVDD EDDCLFLTVD LFTKYATSLI
AMIPLYDHCN DIVLLILRLF SNFTKHQLEY LNQDRARSIF PLIIQLFNSV ATTSSHKKTL
DSKEYYHRVR MMVKILTNII TFGDQRNNCP TIISETIFHA INIITPCLSN NDLLLYPKLA
RNYFMITSFL FGADNIQVKN IPVINTIYSL IEAGILHHDL EIVKSCFECI GCLTKSLENS
KEKSGGLVDP HYQSVLIQFI GSVINFLLLQ DFNVDELLSV ASETLFSLMY SSPDGYRSKV
IELITRQDPS IQSRVVQQFE TLTIIGTDRK SKDLFMKNLQ NFLVNVKSLI NKK
