ID   XPO4_XENLA              Reviewed;        1150 AA.
AC   Q499Y0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Exportin-4;
GN   Name=xpo4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC       substrate specificity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; BC099668; AAH99668.1; -; mRNA.
DR   RefSeq; NP_001089644.1; NM_001096175.1.
DR   AlphaFoldDB; Q499Y0; -.
DR   SMR; Q499Y0; -.
DR   MaxQB; Q499Y0; -.
DR   GeneID; 734704; -.
DR   KEGG; xla:734704; -.
DR   CTD; 734704; -.
DR   Xenbase; XB-GENE-990879; xpo4.L.
DR   OMA; PLSSMIC; -.
DR   OrthoDB; 106880at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 734704; Expressed in heart and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR044189; XPO4/7-like.
DR   PANTHER; PTHR12596; PTHR12596; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1150
FT                   /note="Exportin-4"
FT                   /id="PRO_0000237672"
SQ   SEQUENCE   1150 AA;  130095 MW;  080E2AD5D784D872 CRC64;
     MMAALGASEV IAQLESAAKV LMAPPSMVNN EQRQHAEHVF LSFRKSKSPF AVCKHILETS
     KVDYVLFQAA TAIMEAVVRE WILLEKSSIE SLRTFLLTYV LQRPNLQKYV REQILLAVAV
     IVKRGSLDKS IDCKSIFHEV SQLISSCNPT MQTLACSILT ALLIEFSSSS KTSNIGLSME
     FHGSCKRVFQ DEDLRRIFML TIEVLQEFSR RENLNAQMSS VFQRYLALAN QVLSWNFLPP
     NLGRHYIAMF ESSQNVMLKP TESWRETLLN SRVMELFFTV HRKIREDSDM AQDSLQCLAQ
     LASLHGPIFP DERSQVDYLA HFIEGLLSTI NGIEIEDSEA VGISNIISNL ITVFPRNILT
     AIPSDLFSSF VNCLTHLTCS FGRSAALEEV LDKDDMVYME AYDKLLESWL TLVQDDQHFH
     KGFFTQHAVQ VFNSYIQCHL AAPDGTRNLT ANGVASREEE EINEIQEDDR DLFSDQLASV
     GMLGRIASDH CIPLLTSLLE ERVTRLHGQL QRHQQQLLAS PGADSIDNKV LDDLYEDIHW
     LILVTGYLLA DDTQGETPLI PSEIMEYSIK QSTEVDINTT LQILGSPGEK ASSIPGCNRT
     DSVIRLVSAV LRASEVESRA TRADLTHLLS PQMGKDIVWF LKRWTKTYLL VDEKLYDQIS
     LPFNTAFGAD TEGCHWIIGY LLEKVISNLS VWSSEQELAN ETVQLLVTLV ERRERANLVI
     QCENWWNLAK QFAQRSPPLN FLSSSVQRTL MKALVLGGFA HMDSDTKQQY WTEVLQPLQQ
     RFLNVINQEN FQQICQEEEV KQEITATLEA LCGIAEATQI DNVAILFNFL MDFLTNCIGL
     MEVYKNNPET VNLIIEVFVE VAHKQICYLG ESKAMNLYEA CLTLLQVYSK NNLGRKRIDV
     TAEEDQYQDL LLIMELLTNL LSKEFIDFSD TDEVFRPHEP GQATNRPVSA ADVVLYGVNI
     VLPLMSQDLL KFPSLCNQYY KLITFICEIF PEKIPLLPED LFKSLMYSLE LGMTSMSSEV
     SQLCLEALTP LAEQCAKAQD TDSPLLAAMR HFLKLVFDML VLQKHNTEMT TAAGEAFYTL
     VCLNQAEYAE LVETLLSSQQ DPLIYQRLAD AFNKLTASST PPTLDRKQKM SFLKSLEEFM
     GNVGGLLCVK