XPO5_DICDI
ID XPO5_DICDI Reviewed; 1135 AA.
AC Q54PQ8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Exportin-5;
DE Short=Exp5;
GN Name=xpo5; ORFNames=DDB_G0284379;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the nuclear export of proteins bearing a double-
CC stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos).
CC {ECO:0000250|UniProtKB:Q9HAV4}.
CC -!- FUNCTION: Mediates the nuclear export of micro-RNA precursors, which
CC form short hairpins. {ECO:0000250|UniProtKB:Q9HAV4}.
CC -!- SUBUNIT: Found in a nuclear export complex with RanGTP, exportin and
CC pre-miRNA. {ECO:0000250|UniProtKB:Q9HAV4}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HAV4}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9HAV4}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000250|UniProtKB:Q9HAV4}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AAFI02000064; EAL65238.1; -; Genomic_DNA.
DR RefSeq; XP_638596.1; XM_633504.1.
DR AlphaFoldDB; Q54PQ8; -.
DR SMR; Q54PQ8; -.
DR STRING; 44689.DDB0237583; -.
DR PaxDb; Q54PQ8; -.
DR PRIDE; Q54PQ8; -.
DR EnsemblProtists; EAL65238; EAL65238; DDB_G0284379.
DR GeneID; 8624567; -.
DR KEGG; ddi:DDB_G0284379; -.
DR dictyBase; DDB_G0284379; xpo5.
DR eggNOG; KOG2020; Eukaryota.
DR HOGENOM; CLU_002828_0_0_1; -.
DR InParanoid; Q54PQ8; -.
DR OMA; WPDDPDR; -.
DR PhylomeDB; Q54PQ8; -.
DR PRO; PR:Q54PQ8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0042565; C:RNA nuclear export complex; IBA:GO_Central.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; ISS:dictyBase.
DR GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045478; Exportin-5_C.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR045065; XPO1/5.
DR InterPro; IPR040018; XPO5.
DR PANTHER; PTHR11223; PTHR11223; 1.
DR PANTHER; PTHR11223:SF3; PTHR11223:SF3; 1.
DR Pfam; PF19273; Exportin-5; 1.
DR Pfam; PF03810; IBN_N; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; RNA-binding;
KW Translocation; Transport.
FT CHAIN 1..1135
FT /note="Exportin-5"
FT /id="PRO_0000328542"
FT DOMAIN 32..117
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT REGION 630..631
FT /note="Pre-siRNA binding"
FT /evidence="ECO:0000250|UniProtKB:Q9HAV4"
FT SITE 706
FT /note="Pre-siRNA binding"
FT /evidence="ECO:0000250|UniProtKB:Q9HAV4"
SQ SEQUENCE 1135 AA; 131135 MW; 8C73B724610C3434 CRC64;
MNNDIILVVN QIEQALSLLH DPKSNNKQRE ESQVFLEEIK TRANAHSYAI AIITTSNNDI
LKHFALHIIE TLVKNRWYEC NDQERELIKK EILELMRRIT SNEPKFIKEK LVTILVDVIK
RDWPQRWMNL LTSLIEISKI SDTQTELVLS TFGLLPHDII FDTGSTSQVL SDQRRKDLMA
GINLAVTSLF EYFYQLLESK YTQYKQPTPA TTTTPQQTKQ VIHLINVLLT TLRSYIEWVP
SKVIFDHKLD QIFCQLILDV PFRMGACENL ILFLGRKGRP DERIELIQTP FNFMENFLNS
IKINSDFEDD YSFHKRITQA LTILGTVHLN AYDDKHKIPN NYNIYLQLML QMVSHPSILL
SSFVLPFWHT FIKVESLELS YLEEVIKQIM ETMLVKFVRI GDPEKSDSEQ SKYSEIDFGT
SKEWSNFFGG VRTRYLDIIK LITIQRREMA YIFIATKVAD VLDALKANLN VASLSHEQTL
VLESHSHILD SILLNIKDFT PESSLFFNKE QQQQPNIIQL TDRVLNLLFE INSTEPNITS
FQIDCLQAYI LYYQTNPESI KFLLNKIVPL IPFPGLDNPN RSFQNSVLHT RRRAISSLIG
ISTNISHLMK PYFDILYKSV VELFQKNVVT ETEKVMLFHL LIVFSNNLPS YQQTLDFYKG
ILTPIIEQWV SLEMSTALSS PDAFIQYLGL SIADSQNLDA TLVSRRKNIQ YVASTLQIFW
KKSQIPTNSS DELFAPFISN GISYNGKWPI SSFVKQVLPG VLSLTRTLHQ LWMPEHRAKI
HPSLSTIFNL DDSITAPLLG FEYHKEQKSE SSNVTFLRNI LDCLRDACYE IVGYGFNHSD
ELFSLPDLPL VLLDSVFSYL ESIENRHLKL LVKHILNYLI KNCPTKLEHT IFEPILPLLF
SVLFNRIKAG WELIKLRSQK GEKENEKNEI VEDKILRDVS MEFLMCCSNI ITQSPNYIFS
SIDVMTPMVY GISSCLMAMD TPILKKSLIV STQLLVDHEK VNDPKFFKLI GSEMFGCCIK
ILIVNKFAEF SNDIQSIIRL IYMKYYQICN YPQEILLSLP NITPPILQAF NKDLISTRSE
KSQKVLFKKL LQDVIGIPLN KLKKESILDL PEKLFISKIS DQSNENISNI SNLFN
