ID   XPO6B_XENLA             Reviewed;        1138 AA.
AC   Q6NTZ5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Exportin-6-B;
GN   Name=xpo6-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates the nuclear export of actin and profilin-actin
CC       complexes in somatic cells. Oocyte nuclei lack active actin export (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: Mediates the nuclear export of actin and profilin-actin
CC       complexes in somatic cells. {ECO:0000250|UniProtKB:Q53I77}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53I77}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q53I77}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:Q53I77}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC068807; AAH68807.1; -; mRNA.
DR   RefSeq; NP_001084611.1; NM_001091142.1.
DR   AlphaFoldDB; Q6NTZ5; -.
DR   SMR; Q6NTZ5; -.
DR   DNASU; 414567; -.
DR   GeneID; 414567; -.
DR   KEGG; xla:414567; -.
DR   CTD; 414567; -.
DR   Xenbase; XB-GENE-866274; xpo6.L.
DR   OMA; DYQRRQW; -.
DR   OrthoDB; 214523at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 414567; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040016; XPO6.
DR   PANTHER; PTHR21452; PTHR21452; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1138
FT                   /note="Exportin-6-B"
FT                   /id="PRO_0000235304"
FT   DOMAIN          31..97
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   REGION          291..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..312
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1138 AA;  129843 MW;  1ED84F93291E497F CRC64;
     MASEETSLRA LESLMSEFFH NVTSNERKRE IESLLNNFAQ QLGAWRFCFY FLSESHNDYV
     LMYSLSVFEN LINKMWLGVP SQEKMQIRSS LPKLLLSQHK SLPSFICNKL CKVIVDMGRQ
     DWPMFYHDFF TNILQLIQTP STTPLGLIML KTASEELACP REDLSVARKE ELRKLLLEQV
     PTVLGLLTGV LESIWDKHSI TAATPPPSPT ASDTDDLLSN LIHTPNLTKQ LSQPPPSLEA
     ESERVCALAL ECLSHLFSWI PLSASITPSL LTTIFHFARL GCDARSRHTT SVTTNTTSSV
     VNGGSSSPPL HSAAPTRDRG RLGVLAMSCI NELMCKNCVP LEFQEYLLRV CQQTFYLLQR
     ITRETNAHSV RNRLEELDES YVEKFTDFLR LFVSVHLRRI ESNAQFPVVE FLSLLFKYTF
     HQPSHEGYLS CLDIWALFLD YLTNKIRNRL EDREAIIGRY EDALVLLLTE VLNRIQFRFN
     QTQLEELDDE TLDDDQQTEW QRYLRHSLEV VAKIMELLPT HAFSTLFAAL QENLEVYLGL
     QRCLVTNGND QRLNVTAEND CRRLHCSLRD LSSLLQAVGR LAEYFIGDVF GARFNDALRV
     VERLVEVTLY GSRIKLYNME TAVPSVLKPD LIDVHAQSLA ALQAYSHWLA RYYSEVQRQN
     PEQFISIIST AMEALPPLIS SKVQEKLLLS ACHLLVSIAT TVRPVFLINI PAVQKVFSRI
     TDGSAQRLPE EAQVLLCRAL SNVLLLPWPN VPEGEQQWGE RSSHHANLLN ALTRDYRLLK
     GSSPPQRKGQ LEATKRVICQ TLGVLRDVVE NISGEGTKSR QTCYQSLHES SQLSLALFPA
     YIHQSDVTEE MLSFFLALFQ GLRVQMGAPF TEQIIQTFLN MFTREQLAES ILQEGSAGCH
     VVEKFLKILQ VVVQEPGQAF KPFLPSILSL CMEQLYPIIA ERPSPDVKAE LFELLFQLLH
     HNWRYFYRSS VLASVHRDGS DEPMENQAQF IVVMQAFGQS FLQPDIHIFR QNLSYLETLN
     SKHKLYHKKL FQTVMLPQFV SVLLQVLIHK SHDLLQEEIG IAVYNMASVD FSTFFSAFLP
     EFLTGCQGLD TSQKSVLARN FKMERDLPSF TQSVHRLVND LRYYRLCNDS LPPGTVKL