ID   XPO6_DANRE              Reviewed;        1128 AA.
AC   Q8QHJ8;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Exportin-6;
DE            Short=Exp6;
GN   Name=xpo6;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=14592989; DOI=10.1093/emboj/cdg565;
RA   Stueven T., Hartmann E., Goerlich D.;
RT   "Exportin 6: a novel nuclear export receptor that is specific for
RT   profilin.actin complexes.";
RL   EMBO J. 22:5928-5940(2003).
CC   -!- FUNCTION: Mediates the nuclear export of actin and profilin-actin
CC       complexes in somatic cells. {ECO:0000250|UniProtKB:Q53I77}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53I77}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q53I77}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:Q53I77}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AF395741; AAL78259.1; -; mRNA.
DR   RefSeq; NP_919355.1; NM_194374.1.
DR   AlphaFoldDB; Q8QHJ8; -.
DR   SMR; Q8QHJ8; -.
DR   STRING; 7955.ENSDARP00000099636; -.
DR   PaxDb; Q8QHJ8; -.
DR   PRIDE; Q8QHJ8; -.
DR   GeneID; 333980; -.
DR   KEGG; dre:333980; -.
DR   CTD; 23214; -.
DR   ZFIN; ZDB-GENE-030131-5912; xpo6.
DR   eggNOG; KOG2020; Eukaryota.
DR   InParanoid; Q8QHJ8; -.
DR   OrthoDB; 214523at2759; -.
DR   PhylomeDB; Q8QHJ8; -.
DR   PRO; PR:Q8QHJ8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040016; XPO6.
DR   PANTHER; PTHR21452; PTHR21452; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1128
FT                   /note="Exportin-6"
FT                   /id="PRO_0000239785"
FT   DOMAIN          31..97
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   1128 AA;  128396 MW;  2DEFDDA612302B7F CRC64;
     MASEEASLRA LESLMTEFFH SCTTNDRKRE IEELLNSFAG QPGSWRHWLY FLSNSRNEYV
     MMYSLTVFEN LVNKMWVGVA SEDKAELRSC LPKLLLSQHA LLPFFIRNKL CKVIVDIGRQ
     DWPMFYHDFF SNTLQLVQSP SLASLGLVLL KMTSEELVCP REDLSVARKD ELKKLLLDQI
     PTVLNLLTRI LETVWDKHSV TVTTPPPSPT SRESGVMLGD STPMVLDAES GALCLLALEC
     LAHLFSWIPL SSSITPSLLA SIFHFARFGC QQPIKTKPLP TSNGDSAPGS LPANGGGHCR
     TGQIVGHAER ARLGVMAMNC INELMCKNCV PVDFEEFLLR MFQQTFYLLQ RLTNTHSHTN
     THTIKSRLQD LDESYVEKFT DFLRLFVSVH LRRIESNAQF PLVEFLALLF KYTFNQPSHE
     GYLACLDIWS VFLDYLTTKI RSRLADRDSV INRYKDALVL LLREVLNRIQ FRLNQSQLEE
     LDDETLDDDQ QTEWQRYLRQ SLEVVARVME LLPSQTFSVL FPVLQEDLDV YLGLQQFIVR
     SGTSRRLNIT AEADCRKLHC ALRDLSSLLQ AVGRLAEFFT GDVFTARFND ALAIVQRLVE
     VSCYGSQISL YDVEMAVPSV LKPDLIDVHA QSLAALQAYS HWLAQFCGEV QRQQDQTQFV
     DLITSSMAAA SPLINGKVPE KLLLSACHLL VSMATTVRPV FLVSLPAVQN IFNLITENHN
     HRLPQEAHVL VCRALSNMLL LPWPSLPEGE QQWPNRSANH ARLISSLTQQ YRLLPRPPNH
     HHTSKAVIQQ TLCVLRDLVD SISGEATKSR QICYHSLQES VQVSLALFPL FIQQPEVTDE
     MLSFFLTLFQ ALRVQMGVAF TEQIIQTFLS MFTREQLAVG ILQEGSSGSK VVQKFLKILQ
     VVVQEPGQTF KPLLPSILSL CLDQVYPIVA ERSCPDVRAE MFELLFQILH QNWRFFFKSS
     VLSSVQRSGA EELMENQAQF TAAMQAFGQS FLQPDIHIFK QNLSYLEVLN TKHKLYHRKL
     FRNAMLFHFI NVLLQVLLHK SHDLLQEDIT LALYNMAAVD FSAFYSSFLP EFLNGCQGLD
     PHQRTTLARN FTPERDLPSF SQGVYRIVND LRFYRLCNGS LPPGTLKL