ID   XPO6_DICDI              Reviewed;        1047 AA.
AC   Q54CB2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Exportin-6;
DE            Short=Exp6;
GN   Name=xpo6; ORFNames=DDB_G0293076;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probably mediates the nuclear export of actin and profilin-
CC       actin complexes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000199; EAL60890.1; -; Genomic_DNA.
DR   RefSeq; XP_629307.1; XM_629305.1.
DR   AlphaFoldDB; Q54CB2; -.
DR   SMR; Q54CB2; -.
DR   STRING; 44689.DDB0237584; -.
DR   PaxDb; Q54CB2; -.
DR   EnsemblProtists; EAL60890; EAL60890; DDB_G0293076.
DR   GeneID; 8629030; -.
DR   KEGG; ddi:DDB_G0293076; -.
DR   dictyBase; DDB_G0293076; xpo6.
DR   eggNOG; KOG2020; Eukaryota.
DR   HOGENOM; CLU_004473_0_0_1; -.
DR   InParanoid; Q54CB2; -.
DR   OMA; DYQRRQW; -.
DR   PhylomeDB; Q54CB2; -.
DR   PRO; PR:Q54CB2; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR040016; XPO6.
DR   PANTHER; PTHR21452; PTHR21452; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1047
FT                   /note="Exportin-6"
FT                   /id="PRO_0000328553"
FT   DOMAIN          32..98
FT                   /note="Importin N-terminal"
SQ   SEQUENCE   1047 AA;  119949 MW;  5B4BAB89821B5891 CRC64;
     MNNNDMDQKA KELQNVLEQF YLTTDNPKRK EIDTILNNYK AQSDSYEHVQ YYLVHSDNQY
     VIWFSLSVIE DKVNKAWNSI SASSQTQTKG LLLDIYLNKT GANSNSTVKN VLPQFIISKL
     GQVIADIGRY EFESNPQSYL LNITSIVRNP STSIRGINLL QCISDSFTTN KKVISQQKKT
     TLKKLLHQNS PIIIQVLVDC LGQLFDQNAE KKFKHANLLA FHVGSPDTNT YTASFNAESK
     NLTKAVFDAL LSYFTWVPLS DLLVPSLFDI LFKYLRLDKN SIPALECLNE IVSKNLVPKG
     FESFLMRIFH QVYSLLTDIV SNGGQQINQY HPEFLNKFTQ FIQIFINNHL GRIETNPNFP
     IPDFLGLLFQ YSFFQTQPES FLQCIDIWST FLDYLINLSQ ENGTPPPSKY TDGLLLFQSE
     LVKRILYIFN NNTLSELDDE DKEINENGIS ETQLESYIKK SIEVVAKVTE LYPEKSLENL
     YPLFTQNVTS FFCKAEESIK QGVSMENEQQ FQYLVKDVTT ILHLFGRLAD QFVVSFAQTF
     TAANFIFQKL LDMCLFSVNQ YIYKFGSDWE KLQIELLCTI RSFCFWLAEY GNQVRAIVGQ
     QPDFDSNITK LISIIVPLFE RNAPESILSS AGKLLMSLAT ISKPLNLFTQ MDMLISNIHN
     ICAPLSPSIQ SILYPAISCT ILLPPSNVNL SQQWDQRRPK YSPFIKGITA SFLEIPQIPN
     FVEGKIFCKE ELIQRVLRVL KVVTAIIRTV PEVTQAKSIL HDGIQDTLKV TLGLFRVYIS
     YPIVLEAILD FFFVLFEFLK AQVGVVFTQQ TISTFLDILG GDNLNQLLSS GNDTGISIIK
     KLIEILTFIV QQPGNSFESL LGSTIEFSME KLYPMIANTS SVLRSPFFTL LYSILDNHWK
     QCQQIQINSI LTSFQSIFKQ NDVNLFKQNL DHFEKLNSKL KLYEKISSME PVFGCSFISM
     FFDVLISDTQ SVHTDDIIVT IYRFASLNFD KFFNEFFTTF LVQKNQLSNE QKQILRSNFS
     NAIDQPTFST NMTQFINDFS YFSFINS