ID   XPO7A_XENLA             Reviewed;        1087 AA.
AC   Q704U0;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Exportin-7-A;
GN   Name=xpo7-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN PROTEIN NUCLEAR EXPORT, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Oocyte;
RX   PubMed=15282546; DOI=10.1038/sj.emboj.7600338;
RA   Mingot J.-M., Bohnsack M.T., Jaekle U., Goerlich D.;
RT   "Exportin 7 defines a novel general nuclear export pathway.";
RL   EMBO J. 23:3227-3236(2004).
CC   -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC       substrate specificity. {ECO:0000269|PubMed:15282546}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in oocytes (at protein level).
CC       {ECO:0000269|PubMed:15282546}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AJ620730; CAF05962.1; -; mRNA.
DR   RefSeq; NP_001084497.1; NM_001091028.1.
DR   AlphaFoldDB; Q704U0; -.
DR   SMR; Q704U0; -.
DR   MaxQB; Q704U0; -.
DR   GeneID; 407845; -.
DR   KEGG; xla:407845; -.
DR   CTD; 407845; -.
DR   Xenbase; XB-GENE-6256444; xpo7.S.
DR   OrthoDB; 198413at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 407845; Expressed in testis and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR044189; XPO4/7-like.
DR   InterPro; IPR040021; XPO7.
DR   PANTHER; PTHR12596; PTHR12596; 1.
DR   PANTHER; PTHR12596:SF11; PTHR12596:SF11; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..1087
FT                   /note="Exportin-7-A"
FT                   /id="PRO_0000237675"
FT   DOMAIN          30..96
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   1087 AA;  123160 MW;  5C712B5163A80DC0 CRC64;
     MADPVQSLAQ LEILCKQLYE TTDTSTRLQA EKALVEFTNS SECLSKCQLL LERGSSSYSQ
     LLAATCLTKL VSRSTNPLPL EQRIDIRNYV LTYLATRPKL ASFVTQALIQ LYARITKLGW
     FDSQKDEYVF RSVIGDVTRF LQDSVEYCVI GVSILSQLTN EINQADATHP LTKHRKIASS
     FRDSALFEIF TLSCNLLKQA SGKSLLLSDG SQHDLLMQLL KLTHNCLNFD FIGTSTDESS
     DDLCTVQIPT SWRSAFLDSS TLQLFFDLYH SIPPNFSPLV LSCLVQIASV RRSLFNNAER
     AKFLSHLVDG VKRILENPQS LSDPNNYHEF CRLLARLKSN YQLGELVKVE NYPEVIRLIA
     NFTVTSLQHW EFAPNSVHYL LSLWQRLAAS VPYVKATEPH LLETYTPEVT KAYVTSRLES
     VHIILRDGLE DPLEDAGLVQ QQLDQLSTIG RCEYDKTCAL LVQLFDQSAQ TYQELLQSGS
     APSMELAVQE GRLTWLVYII GAVIGGRVSF ASTDEQDAMD GELVCRVLQL MNLTDSRLAQ
     AGNEKLELSM LSLFEQFRKI YIGDQVQKSS KLYRRLSDVL GLNDETMVLS IFIGKIITNL
     KYWGRCEPIT SKTLQLLNDL SIGYSSVRKL VKLSAVQFML NNHTSEHFSF LGINSQSNLS
     DMRCRTTFYT ALGRLLMVDL GEDEEQFSQF MMPLTAAFES LAQMFNSNNF NEQEAKRSLV
     GLVRDLRGIA FAFNAKSSFM MLFDWIYPAY MPILQRAIEL WFHDPACTTP ILKLMAELVH
     NRSQRLQFDV SSPNGILLFR ETSKMITTYG NRILTLGELP KEQLYVLKLK GISICFSVLK
     AALSGNYVNF GVFRLYGDEA LDNALQTFVK LLLSVPHSDL LDYPKLSQSY YSLLEVLTQD
     HMSFIASLEP HVIMYILSSI SEGLTALDTM VCTGCCSCLD HIVTYLFKQL SRSGKKRGAP
     PPQESERFLH IMQQHPEMIQ QMLSTVLNII IFEDCRNQWS MSRPLLGLIL LNEKYFSDLR
     SSIVSSQPPE KQQAMHLCFE NLMEGIEGNL LTKNRDRFTQ NLSAFRREVN DSMKNSSCGP
     NSNEMMS