XPO7_DICDI
ID XPO7_DICDI Reviewed; 1007 AA.
AC Q54DN3;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Exportin-7;
DE Short=Exp7;
GN Name=xpo7; Synonyms=Ranbp7; ORFNames=DDB_G0291986;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the nuclear export of proteins (cargos) with broad
CC substrate specificity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Nucleus, nuclear pore complex {ECO:0000250}. Note=Shuttles between the
CC nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61349.2; -; Genomic_DNA.
DR RefSeq; XP_629839.2; XM_629837.3.
DR AlphaFoldDB; Q54DN3; -.
DR SMR; Q54DN3; -.
DR STRING; 44689.DDB0233670; -.
DR PaxDb; Q54DN3; -.
DR ABCD; Q54DN3; 2 sequenced antibodies.
DR EnsemblProtists; EAL61349; EAL61349; DDB_G0291986.
DR GeneID; 8628520; -.
DR KEGG; ddi:DDB_G0291986; -.
DR dictyBase; DDB_G0291986; xpo7.
DR eggNOG; KOG1410; Eukaryota.
DR HOGENOM; CLU_005409_1_1_1; -.
DR InParanoid; Q54DN3; -.
DR OMA; VKCQWSL; -.
DR PhylomeDB; Q54DN3; -.
DR PRO; PR:Q54DN3; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0005049; F:nuclear export signal receptor activity; ISS:dictyBase.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR044189; XPO4/7-like.
DR PANTHER; PTHR12596; PTHR12596; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transport.
FT CHAIN 1..1007
FT /note="Exportin-7"
FT /id="PRO_0000328523"
SQ SEQUENCE 1007 AA; 117160 MW; 73F18C53057CB4A3 CRC64;
MSIQSEQDFF KFEELCKDFY LKPEETIKID DILHQYFLNP NFLIEYKQIL SFTKNSYVVA
QVIRGLIKCV TSFWTSLTPN QKNDMSKSIE HHCIGLRILK DIISEFNEYI GEHLTVLQHR
NISISLRDNI LLDIFCISLE SLNYALANSM DEKFKSIKEL ALDLSYSCLS FDFIKTTSID
SSEEILTVQI PSQWKSTFDE NNPLELFFKI YKQYHSTKSL ECILQIVSIR RSFFTTEDER
VKFLASIVQY TTEILKSNIG FNEPNNHLVF SRVIERLKTN YHLNNLVTVV GYNDWISNLS
TFTIDTLKNP QFSPNSIYFL LTLWAKLVSS IIYVKGDPSK TYLEKYSPII MESFINSKID
NSYSDEEDEH LMDYEKMVEI LEGIPHLGRI TYQATCRQII LLFDSISSKF LNETNPTQLE
VYERQCAWLV YIIGCLILGR TSINSSEEHD KIDGELSVRV FILIGYNDKK LSAESNTQYQ
YRTSRISLEL SFIYFMQNFR RIYIGENSIS SSKIYQRISE LSGPTDHTSV LFSIVQKIGF
NFKYWAENDE IIKKSLDMFW ESVNGHSTSK MLIDNKITKD ILKTHSSQVF PFLEKNSNPR
NRTSLYKTIG KLLFTDENMG FFDEFIAPFD DTIKHLLNIS TPEQFRTEEI KRKVIGLLRD
LRGIITSANS KRSYLLFFEW IHLNFSEVLI KIINVWVDSP EVTTSLLKFI SEFVFNRQSR
LIFDSSSANG FIIFRDTSKI LVSYASLILK ANISKQDLYK FKIKGIQTSM LLFTRCLVGG
YCNFGVFELY GDPSFTSAID YIFQLCLSVS LDELMSFPKA SKAYVTMLEA LCLGHTLSII
QLNQQYFIHI MKSLHRCLDS QDVTMSSSSC TSIEKIITVC YYHLKKKNSQ CLQAIHQNFF
SNSNILYEII DKIISIIIYE DNFNQFMFSK LLLTCIIFHQ DTFTTLKQKY IHSFNSQCPE
KVEKAFVQLM ENTLDNLETK NKDKFTSNVS IFRKEMKLIS SSTGRYL