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XPOT_ARATH
ID   XPOT_ARATH              Reviewed;         988 AA.
AC   Q7PC79; Q7XAC4; Q9CAH2;
DT   22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Protein PAUSED;
DE   AltName: Full=tRNA exportin;
GN   Name=PSD; OrderedLocusNames=At1g72560; ORFNames=F28P22.25;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION
RP   PHENOTYPE.
RC   STRAIN=cv. Landsberg erecta;
RX   PubMed=12913148; DOI=10.1104/pp.103.023291;
RA   Li J., Chen X.;
RT   "PAUSED, a putative exportin-t, acts pleiotropically in Arabidopsis
RT   development but is dispensable for viability.";
RL   Plant Physiol. 132:1913-1924(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=cv. Columbia;
RX   PubMed=12913168; DOI=10.1104/pp.103.023309;
RA   Hunter C.A., Aukerman M.J., Sun H., Fokina M., Poethig R.S.;
RT   "PAUSED encodes the Arabidopsis exportin-t ortholog.";
RL   Plant Physiol. 132:2135-2143(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [5]
RP   FUNCTION.
RX   PubMed=15738428; DOI=10.1073/pnas.0405570102;
RA   Park M.Y., Wu G., Gonzalez-Sulser A., Vaucheret H., Poethig R.S.;
RT   "Nuclear processing and export of microRNAs in Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3691-3696(2005).
CC   -!- FUNCTION: Probable tRNA nucleus export receptor which regulates tRNA
CC       processing and facilitates tRNA translocation across the nuclear pore
CC       complex. Is required for proper activity of the shoot apical meristem
CC       (SAM) and correct leaf initiation at different developmental stages,
CC       and may play a role in floral patterning. {ECO:0000269|PubMed:12913148,
CC       ECO:0000269|PubMed:12913168, ECO:0000269|PubMed:15738428}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in young leaves, growing leaf blades,
CC       young floral organs and root tips. {ECO:0000269|PubMed:12913148}.
CC   -!- DISRUPTION PHENOTYPE: Delayed leaf formation during vegetative
CC       development, abnormal SAM layered structure, altered inflorescences,
CC       disrupted phyllotaxy, reduced number of seeds and reduced number of
CC       lateral roots. {ECO:0000269|PubMed:12913148,
CC       ECO:0000269|PubMed:12913168}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51863.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY288073; AAP37047.1; -; mRNA.
DR   EMBL; BK001280; DAA01277.1; -; Genomic_DNA.
DR   EMBL; AC010926; AAG51863.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE35340.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35341.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35342.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM59601.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM59602.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM59603.1; -; Genomic_DNA.
DR   EMBL; CP002684; ANM59604.1; -; Genomic_DNA.
DR   PIR; A96750; A96750.
DR   RefSeq; NP_001077813.1; NM_001084344.1.
DR   RefSeq; NP_001185383.1; NM_001198454.2.
DR   RefSeq; NP_001321946.1; NM_001334539.1.
DR   RefSeq; NP_001321947.1; NM_001334541.1.
DR   RefSeq; NP_001321948.1; NM_001334542.1.
DR   RefSeq; NP_001321949.1; NM_001334540.1.
DR   RefSeq; NP_177400.2; NM_105915.4.
DR   AlphaFoldDB; Q7PC79; -.
DR   SMR; Q7PC79; -.
DR   STRING; 3702.AT1G72560.3; -.
DR   PaxDb; Q7PC79; -.
DR   PRIDE; Q7PC79; -.
DR   ProteomicsDB; 242493; -.
DR   EnsemblPlants; AT1G72560.1; AT1G72560.1; AT1G72560.
DR   EnsemblPlants; AT1G72560.2; AT1G72560.2; AT1G72560.
DR   EnsemblPlants; AT1G72560.3; AT1G72560.3; AT1G72560.
DR   EnsemblPlants; AT1G72560.4; AT1G72560.4; AT1G72560.
DR   EnsemblPlants; AT1G72560.5; AT1G72560.5; AT1G72560.
DR   EnsemblPlants; AT1G72560.6; AT1G72560.6; AT1G72560.
DR   EnsemblPlants; AT1G72560.7; AT1G72560.7; AT1G72560.
DR   GeneID; 843588; -.
DR   Gramene; AT1G72560.1; AT1G72560.1; AT1G72560.
DR   Gramene; AT1G72560.2; AT1G72560.2; AT1G72560.
DR   Gramene; AT1G72560.3; AT1G72560.3; AT1G72560.
DR   Gramene; AT1G72560.4; AT1G72560.4; AT1G72560.
DR   Gramene; AT1G72560.5; AT1G72560.5; AT1G72560.
DR   Gramene; AT1G72560.6; AT1G72560.6; AT1G72560.
DR   Gramene; AT1G72560.7; AT1G72560.7; AT1G72560.
DR   KEGG; ath:AT1G72560; -.
DR   Araport; AT1G72560; -.
DR   TAIR; locus:2030280; AT1G72560.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_1_1_1; -.
DR   InParanoid; Q7PC79; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   PhylomeDB; Q7PC79; -.
DR   PRO; PR:Q7PC79; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q7PC79; baseline and differential.
DR   Genevisible; Q7PC79; AT.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IGI:TAIR.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0009908; P:flower development; IMP:TAIR.
DR   GO; GO:0010014; P:meristem initiation; IMP:TAIR.
DR   GO; GO:0006409; P:tRNA export from nucleus; IGI:TAIR.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Receptor; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..988
FT                   /note="Exportin-T"
FT                   /id="PRO_0000415612"
FT   CONFLICT        78
FT                   /note="Q -> K (in Ref. 1; AAP37047)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213
FT                   /note="V -> G (in Ref. 1; AAP37047)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        594
FT                   /note="T -> S (in Ref. 1; AAP37047)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   988 AA;  111462 MW;  EFE671CC502A00E5 CRC64;
     MDDLEQAIVI SFETGAVDSA LKSQAVTYCQ QIKETPSICS ICIEKLWFSK LVQVQFWCLQ
     TLQDVLRVKY GSMSLDEQSY VRKSVFSMAC LEVIDNENAG RVVEGPPFVK NKLAQVLATL
     IYYEYPLIWS SVFLDFMLHL CKGAVVIDMF CRVLNALDDE LISLDYPRTP EEISVAARVK
     DAMRQQCVPQ IARAWYDIVS MYKNSDPDLS ATVLDCMRRF VSWIDIGLVA NDAFVPLLFE
     LILSDGLSEQ VRGAAAGCVL AMVSKRMDPQ SKLPLLQTLQ ISRVFGLVSG DVDSDLVSKV
     SALLTGYAVE VLECHKRLNS EDTKAVSMDL LNEVLPSVFY VMQKCEVDST FSIVQFLLGY
     VSTLKGLPAL KEKQLLHITQ ILEVIRIQIC YDPMYRNNLN SLDKTGLEEE DRMSEFRKDL
     FVLLRTVGRV APEVTQHFIR NSLANAVESS SESNVEEVEA ALSLLYSFGE SMTEEAMKTG
     SGCLSELIPM LLTTQFPGHS HRLVALVYLE NITRYMKFIQ ENSQYIPNVL GAFLDDRGLH
     HQNFYVSRRA GYLFMRVVKL LKSKLVPFID KILQNLQDTL SQLTTMNFAS RELTGTEDGS
     HIFEAIGIII GLEDVPAEKQ SDYLSLLLTP LCQQIEAGLV QAKVASSEDF PVKIANIQFA
     IVAINALSKG FNERLVTASR PGIGLMFKQT LDVLLRVLIE FPKVEPLRSK VTSFIHRMVD
     TLGSAVFPYL PKALEQLLAD SEPKEMVGFM VLLNQLICKF NSALHDILEE VYPVVAVRIF
     NVIPRDGLPS RPGAVTEEMR ELIELQRMLY TFLHVIATHD LSSVFLTPKS RAYLDPMMQL
     VLNTSCNHKD ITVRKACVQI FIKLIKDWCA EPYSEEKVPG FQNFVIEAFA TNCCLYSVLD
     KSFNFSDANT HALFGEIITA QKVMYEKFGN TFLMHLMSKS FPSAHIPQDL AEQYCQKLQG
     NDIRSLKSYY QSLIENLRLQ QNGSHVFR
 
 
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