ID   XPOT_ASHGO              Reviewed;        1051 AA.
AC   Q753A0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=AFR424C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 284.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS53795.2; -; Genomic_DNA.
DR   RefSeq; NP_985971.2; NM_211326.2.
DR   AlphaFoldDB; Q753A0; -.
DR   SMR; Q753A0; -.
DR   STRING; 33169.AAS53795; -.
DR   PRIDE; Q753A0; -.
DR   EnsemblFungi; AAS53795; AAS53795; AGOS_AFR424C.
DR   GeneID; 4622244; -.
DR   KEGG; ago:AGOS_AFR424C; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q753A0; -.
DR   OMA; RFSPLCW; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1051
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343078"
SQ   SEQUENCE   1051 AA;  117054 MW;  6AE3A0D8E8F3CA0B CRC64;
     MSQQLQQAVE IAYSSTAEPA LKKQALEYVQ NVKAGAGAAE VFVGYLGDAG TSDVGRFVAL
     QALSELAGEG GPARLAFLKD SAMRALRGET GGVWGAPEYV RNKTAEWVSR LFYAMYGEVN
     GNMWNSFFED VAQATGVAGL RGSAAVEYNA AGLDAFLRVC AAINSEIGDQ TFVRSKDAQV
     KNNSLKDAMR VQDVATLTSI WRHALEAMRQ DVQRQDVAVL VLQCIGSFIS WIDINLIVNS
     EYISTIYAYL NYPKTRIACA QCLCEILSKK MKPGDKLQLL GMLSLTDKVL QLGDVEVEVH
     EQLAKLTSSV GLELSVILEQ CHDDSSSAGS CSIANSADHQ IIHQVAPLVL KFMNHEYDSV
     TQQTFPFISH YLTFLKRLFA LGGKPGSAVA LNSKKLPLDD DHRQFLTSLI IVCMNKMKFD
     ETCSYDDEDE VEEFVETVRS KLKVFQDNIA VINPAIYMEN ISKHIKSLLL GNSWRDLELA
     IYQMHNFAES IRNNLFGLNK SAISQSQPAQ LMTTFMQDIL DNSAIFQSSN PLIQISFFEL
     IVRHYNFISH TGKNDISILS IFCTPFSMFN DSEKVRLRSW YLFSRLIKVT KPRLDDESLS
     QLLSKLAPLL AVKLLPNVAN DSEIDTTFDN QLYIFEGVGI LIGAKAKEEY SILDGVLSPL
     FADLESCIAA PVKSPEIVVQ AHHILMAIGT IARGVHAGLV PENQLNNPQV NAALVHKSLI
     EKFSNIAEVI LVTFSYFNKY ETIRDATRFS FARLTPILKN DIIPFSSRLI SIFLESDLKT
     IEMNDFLGFL GQMVHTFHAD DNCYQLFNNL FTPVIKKVFD LVAQVEQEGS LASGANTAPA
     VSKVANGKNV VITDSFRDKV QLKKAYYSFL QSFVSNNVTS LLLTTANRNI LPLILSDLLS
     YTPAEIHETS SMKLSLNVLI NFVKFFGTGR CADFKDRNAN TFEPLEGLSE FFITKVVPLV
     FEIPFKPEYE FNIDDGSCLV LAADLSRLLK ALYDVNGDPA NNASLKYLTE AYFPQVQFPQ
     ELSMEFIQTL ATADEKAFEK YFVSFIKRMR S