ID   XPOT_ASPCL              Reviewed;        1029 AA.
AC   A1CAU2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=ACLA_012880;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; DS027049; EAW12860.1; -; Genomic_DNA.
DR   RefSeq; XP_001274286.1; XM_001274285.1.
DR   AlphaFoldDB; A1CAU2; -.
DR   SMR; A1CAU2; -.
DR   STRING; 5057.CADACLAP00001401; -.
DR   EnsemblFungi; EAW12860; EAW12860; ACLA_012880.
DR   GeneID; 4706423; -.
DR   KEGG; act:ACLA_012880; -.
DR   VEuPathDB; FungiDB:ACLA_012880; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1029
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343079"
SQ   SEQUENCE   1029 AA;  114652 MW;  C12498667EB373FD CRC64;
     MEEQVANAIE IASNPSSEPA LKAQAFDFVN QLRSDPSGWQ VCLSLFTQTP QRSGIVRHVA
     LEVVNGAAQG GLIDLQALAF VKDGLLAYLR QVYGQDAGAS DPPNIQNKIA QTVTFLFSAL
     YANGWETFFD DLLSLTYKSP SSTARDNASG IIFYLRVINS IHDEIGDVLV SRSRNEQDKA
     NSLKDLIRQR DMQQITSSWQ QILSEWRDGN DVIVEMCLKA VGSWVSWIDI GLVVNQTMLD
     LLFQQLGRAQ KADLRQGEEK VRDAAVDVFT EIIGKKMKAE DKIDMIIFLN LDTIVSQLSN
     SPPLHANRFT FKYDTDLAET VAKLVNITVI DIVRALEQEG VSAECKEKAN GLLQVFLPHI
     LRFFSDEYDE VCSTVIPCVS DLLTYLRKIA KINPALAAQH SSILLPILKA IIAKMRYDDT
     SSWGDEDDQT DEAEFQELRK RLGVLQQIVA SVNEQLYMEA VSEVVGTTFE NLRQSGAQLD
     WRDLDLALHE MFLFGDLAVK AGSLYTKGSP NNQAAERLIE MMLRMVESDI RSFTHPATQL
     QYMEICVRYS SFFHHHTHLI PGVLESFLQL VHHPVKKVKT RSWYLFQRLV KQLRQYIGNV
     AQTVVEALGD LLVIQAEVSP EGSDGDEMSS EDHEGSADAV FNSQLYLFEA VGIICSTPTV
     PADKQVLYAQ SVLNPIFLDM EKNLEAAKSH DERALLQIHH DIMALGTLAR GFSDWMPGTN
     TPATLPAPEV SEAFNQVSEA TLVALESLKT SFNVRTAARF AFSRLIGVLG SRILPQLPRW
     IDGLLTQTSS RDEMALFLRL LDQVIFGFKG EIYSILDTLL TPFLQRVFSG IADPTTGTDD
     EIRLAELKRE YLNFLLAVLN NDLGAVIISE RNQPIFETVI STIEHFSKDI DDFTTAKMAF
     SVLSKMGSSW GGPDIAPDAT NGVPPQAALP GFSQFMISRF SPLCWALPTT PSFNSKDAQA
     RQVLAEAGGL QRTIYSKTGM EYIAYLRDRE LPGMGMGGEL IEEFLGALSR LDLKGFRQFF
     PSFIQRLSA