ID   XPOT_ASPFC              Reviewed;        1032 AA.
AC   B0Y4D6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=AFUB_057410;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP51727.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS499597; EDP51727.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; B0Y4D6; -.
DR   SMR; B0Y4D6; -.
DR   PhylomeDB; B0Y4D6; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; RNA-binding; Transport; tRNA processing; tRNA-binding.
FT   CHAIN           1..1032
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343080"
SQ   SEQUENCE   1032 AA;  115410 MW;  C032B1D6D84EE4ED CRC64;
     MEEQVANAIE IASNPSADPA LKTQAFDFVN QLRSDPSGWQ VCLSLFTQTP QRSGIVRHVA
     LEVVNSAAQG GLIDLQALAY VKDGLLAYLR QVYGQDAGAS DPPNIQNKIA QTITFLFSAL
     YASGWESFFD DLLGLTQKSP SSTTRDNASG IIFYLRVINS IHDEIGDVLV SRSRNEQDKA
     NALKDLIRQR DMQKITSSWQ QILSEWRDGN DVIVEMCLKA VGSWVSWIDI GLVVNQTMLD
     LLFRQLGRAQ KEDLRQGEEK VRDAAVDVFT EIIGKKMKPE DKIDMIIFLN LDTIVSQLSN
     SPPLHGNRFT FKYDTDLAET VAKLVNITVI DIVRALEQEG VSTECKEKAN GLLQAFLPHI
     LRYFSDEYDE VCSTVIPCVS DLLTYLRRIA KVNPALASQH SSILLPILKA IIAKMRYDET
     SSWGEEDEQT DEAEFQELRK RLGILQQMIA SINEQLYMEV VSEMVATTFE NLRQSGSQMD
     WRDLDLALHE MFLFGDLAVK AGSLYTKGNP NNQAAERLIE MMLRMVESDI RSFTHPATQL
     QYTEICVRYS SFFHHHTHLI PGVLENFLQL VHHPIKKVKT RSWYLFQRLV KQLRQYVGNV
     AQTVVEALGD LLVIRAELPS EVSEGDEMSS EDHELADAIF NSQLYLFEAV GIICSTPTIS
     PDKQVLYLQA VLNPIFLDME KNLEAAKSQD ERAILQIHHD IMALGTLARG FSDWMPGTNT
     PATLPAPEVS AAFNQVAEAT LVALESLKSS FNVRTAARFA FSRLIGVLGS RILPQLPRWI
     DGLLTQTSSR DEMALFLRLL DQVIFGFKGE IFSILDTLLT PFLQRVFSGI ADPTTGTDDE
     IQLAELKREY LNFLLAVLNN DLGAVIISER NQPIFETVIS TIEHFSKDID DFTTAKMAFS
     VLSKMSSSWG GPDVIAEASN GTPPSQAPLP GFGQFMITRF SPLCWALPST PSFNSKDAQA
     KQVLAEAGGL QRTIYAKTGM EYLTYLRDRE LPGMGMGGEL IEEFVGALSR LDLKGFRQFF
     PVCLSNFHIL SI