XPOT_ASPFU
ID XPOT_ASPFU Reviewed; 1032 AA.
AC Q4WUV9;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=los1; ORFNames=AFUA_5G09850;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL91617.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAHF01000003; EAL91617.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_753655.1; XM_748562.1.
DR AlphaFoldDB; Q4WUV9; -.
DR SMR; Q4WUV9; -.
DR STRING; 746128.CADAFUBP00005620; -.
DR GeneID; 3511549; -.
DR KEGG; afm:AFUA_5G09850; -.
DR eggNOG; KOG2021; Eukaryota.
DR InParanoid; Q4WUV9; -.
DR OrthoDB; 142520at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1032
FT /note="Exportin-T"
FT /id="PRO_0000343081"
SQ SEQUENCE 1032 AA; 115368 MW; 723D55153308BDA8 CRC64;
MEEQVANAIE IASNPSADPA LKTQAFDFVN QLRSDPSGWQ VCLSLFTQTP QRSGIVRHVA
LEVVNSAAQG GLIDLQALAY VKDGLLAYLR QVYGQDAGAS DPPNIQNKIA QTITFLFSAL
YASGWESFFD DLLGLTQKSP SSTTRDNASG IIFYLRVINS IHDEIGDVLV SRSRNEQDKA
NALKDLIRQR DMQKITSSWQ QILSEWRDGN DVIVEMCLKA VGSWVSWIDI GLVVNQTMLD
LLFQQLGRAQ KEDLRQGEEK VRDAAVDVFT EIIGKKMKPE DKIDMIIFLN LDTIVSQLSN
SPPLHGNRFT FKYDTDLAET VAKLVNITVI DIVRALEQEG VSTECKEKAN GLLQAFLPHI
LRYFSDEYDE VCSTVIPCVS DLLTYLRRIA KVNPALASQH SSILLPILKA IIAKMRYDET
SSWGEEDEQT DEAEFQELRK RLGILQQMIA SINEQLYMEV VSEMVATTFE NLRQSGSQMD
WRDLDLALHE MFLFGDLAVK AGSLYTKGNP NNQAAERLIE MMLRMVESDI RSFTHPATQL
QYTEICVRYS SFFHHHTHLI PGVLENFLQL VHHPIKKVKT RSWYLFQRLV KQLRQYVGNV
AQTVVEALGD LLVIRAELPS EVSEGDEMSS EDHELADAIF NSQLYLFEAV GIICSTPTIS
PDKQVLYVQA VLNPIFLDME KNLEAAKSQD ERAILQIHHD IMALGTLARG FSDWMPGTNT
PATLPAPEVS AAFNQVAEAT LVALESLKSS FNVRTAARFA FSRLIGVLGS RILPQLPRWI
DGLLTQTSSR DEMALFLRLL DQVIFGFKGE IFSILDTLLT PFLQRVFSGI ADPTTGTDDE
IQLAELKREY LNFLLAVLNN DLGAVIISER NQPIFETVIS TIEHFSKDID DFTTAKMAFS
VLSKMSSSWG GPDVIAEASN GTPPSQAPLP GFGQFMITRF SPLCWALPST PSFNSKDAQA
KQVLAEAGGL QRTIYAKTGM EYLTYLRDRE LPGMGMGGEL IEEFVGALSR LDLKGFRQFF
PVCLSNFHIL SI