ID   XPOT_ASPNC              Reviewed;        1030 AA.
AC   A2QMS5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=An07g03150;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AM270126; CAL00249.1; -; Genomic_DNA.
DR   RefSeq; XP_001391398.1; XM_001391361.2.
DR   AlphaFoldDB; A2QMS5; -.
DR   SMR; A2QMS5; -.
DR   PaxDb; A2QMS5; -.
DR   EnsemblFungi; CAL00249; CAL00249; An07g03150.
DR   GeneID; 4981582; -.
DR   KEGG; ang:ANI_1_386064; -.
DR   VEuPathDB; FungiDB:An07g03150; -.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   Proteomes; UP000006706; Chromosome 4L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1030
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343082"
SQ   SEQUENCE   1030 AA;  114779 MW;  3EAA6B35285461F3 CRC64;
     MEEQVANAIE IAGNPTSDQT LKAQAFDYLN QLRTDPSGWQ VCLTLFTKTP QYSEIIRHVA
     LEVVNSAAQA GLIDPQALGY VRDGLMAYLR QVYGQDNVTP DSTSIQNKIA QTITFLFSAL
     YGNGWETFFD DLLSLTYKSS ASTSHDNPLG IVFYLRVINA IHEEIGDVLV SRSRTEQDKA
     NLLKDLIRSR DMQKIASSWQ QILSEWRDGN DTIVEMSLRA VGSWVSWIDI GLVVNQTTLD
     LLFQQLGRAQ KAELREGEEK VRDAAVDVFT EIIGKKMKPE DKMDMIIFLN LDTIVTQLSN
     SPPLHENRFT FKYDTDLAET VAKLVNITVI DIVRALEQDT VTADCKAKAT GLLQAFLPHI
     LRYFSDEYDE VCSTVIPCVS DLLSYLRKIA KVNPALAEQH SSILLPILKA IIAKMRYDET
     SSWGDEDDQT DEAEFQELRK RLGVLQQIVA SVNEQLCMEA VSEVVGNTFE SLRQSGAQLD
     WRDLDLALHE MFLFGEVAVR AGSLYSKGVP NNAAAERLVE MMLKMVESDI RSFTHPATQL
     QYMEICVRYS SFFQYHTHLI PTVLESFLQL VHHPIKKVKT RSWYLFQRLV KQLRTHVGNV
     AQTVVEALGD LLVINAELPT EGSDGDEMSS EDHEGSADAV FNSQLYLFEA VGIICSTPTV
     PADKQVLYAQ SVLNPVFMDM EKNLAPAKAN DERALLQIHH DIMALGTLAR GFSDWMPGTS
     SPASLPAPEV SEAFMQVSEA TLVALESLKT SFNVRTAARF AFSRLIGVLG SRILPQLPRW
     IDGLLTQTSS RDEMALFLRL LDQVIFGFKS EIYSILDALL TPFLQRVFSG IADAPTGTDD
     EVQLAELKRE YLNFLLAVLN NELGAVIISE RNQPMFETVI GTIEHFAKDI EDFTTAKMAF
     SVLSKMGSSW GGPDITPEGA NGAAPQQQAL PGFGQFMITR LSPLCWALPA TPSFNSKDAQ
     AKQVLAEAGG LQRTIYAKTG MEYLQYLRDR ELPGMGMGAD LVEEFVGALG RLDMKGFRQF
     FPSFIQRLSA