ID   XPOT_ASPOR              Reviewed;        1026 AA.
AC   Q2U3V3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=AO090020000604;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE63762.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP007167; BAE63762.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q2U3V3; -.
DR   SMR; Q2U3V3; -.
DR   STRING; 510516.Q2U3V3; -.
DR   EnsemblFungi; BAE63762; BAE63762; AO090020000604.
DR   Proteomes; UP000006564; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1026
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343083"
SQ   SEQUENCE   1026 AA;  114661 MW;  8D3D8EE195C6DD86 CRC64;
     MEEQVANAIE IAWNPSSDQA LKAQAFDYLN QLRTDPSGWQ VCLALFTKTP QHSEIIRHVA
     LEVVNSAAQA GLIDPQALGY VRDGLMNYLR QVYGQENANP DPPNIQNKIA QTITFLFSAL
     YGSGWESFFD DLLSLTYKGA SSTSPDNMLG IVFYLRVVNS IHDEIGDVLV SRSRTEQDRA
     NSLKDLIRMR DMQKIASSWQ QILSEWRDGN DLIVEMCLKA VGSWVGWIDI SLVVNQTMLD
     LLFQQLARAQ KAELRAGEEK VRDAAVDVFT EIIGKKMKPE DKIDMIIFLN LDTIVSQLSN
     SPPLCENRFT FKYDTDLAET VAKLVNSTVV DIVRALEQEN ISAECREKAN GLLQAFLPHI
     LRYFSDEYDE VCSTVIPCGS DLLQYLRKVS KTDPSLTAQH SPILLPILKA IIAKMRYDET
     SSWGDEDDQT DEAEFQELRK RLAIMQQTVA SVNEQLYIDA VSEVVATTFE NLRQSGAQLD
     WRDLDLALHE MFLFGDIAVK AGSLYTKNQP NNQAAERLIE MMSRMVESDI RSFTHPATQL
     QYMEICVRYS SFFLYHTNLI PGVLESFLQL VHHPTKKVKT RSWYLFQRLV KQLRSHIGNV
     AQTVVQALGD LLVIQAEIPT EGADGDEMSS EDHEGSADAV FNSQLYLFEA VGIICSTPTV
     AADKQVLYVQ SVLNPVFMDM EKNLAPAKSN DERALLQIHH DIMALGTLAK GFSDWMPGTS
     SPTSLPAPEV SEAFLQVSEA TLVALESLKT SFNIRTAARF AFSRLIGVLG SRILPQLPRW
     IDGLLTQTST RDEMALFLRL LDQVIFGFKG EIYAILDTLL TPFLQRVFAG IADPTTGTDD
     EIQLAELKRE YLNFLLAVLN NDLGAVIISE RNQPMFDTVI TTIEHFAKDI EDFTTAKMAF
     SVLSKMGSSW GGPDIAPEAT NGASQQVALP GFAQFMISRM SPLCWALPAT PSFNPKDAQA
     KQVLAEAGGL QRTIYCKTGM EYIQYLRDQE LPGMGMGGEL IEEFLNALGQ LDLKGFRQFF
     PVCTAR