ID   XPOT_ASPTN              Reviewed;        1028 AA.
AC   Q0CIL3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=ATEG_06471;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU33015.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CH476602; EAU33015.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001215649.1; XM_001215649.1.
DR   AlphaFoldDB; Q0CIL3; -.
DR   SMR; Q0CIL3; -.
DR   STRING; 341663.Q0CIL3; -.
DR   EnsemblFungi; EAU33015; EAU33015; ATEG_06471.
DR   GeneID; 4322248; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1028
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343084"
SQ   SEQUENCE   1028 AA;  113758 MW;  5D5DFE7BBC43F405 CRC64;
     MEEQVVNAIQ IASNPSADQA LKAQAFDYVN QLRSDPSGWQ ICLALFTKTP QHSEVVRHVA
     LEVVNSAAQA GLIDPQALGY VRDGLMAYLR QVYAQETATP DSPGIQNKIA QTITFLFSAL
     YGNGWESFFD DLLSLTYKSP SSTGRDNAPG IVFYLRVINS IHDEIGDVLV SRSRAEQDKA
     NSLKDLIRMR DMQKIAGSWQ EILSDWRDGN DIIVEMALKA VGSWVSWIDI GLVVNQTMLD
     LLFQQLARAQ KADLRAGEDK VRDAAVDVFT EIVGKKMKAE DKVDMIIFLN LDTIVSQLSN
     SPPLHENRFT FKYDTDLAET VAKLVNITVC DIIRALENES TTPESKEKAG GLLQAFLPHI
     LRYFSDEYDE VCSTVIPCVS DLLQYLRKIA KSNPALAAQH SSTLLPILKA IIAKMRYDET
     SSWGDEDDQA DEAEFQELRK RLGVLQQSIA AVNEQLYIDA VSEVVGTTFE NLRQSGAQVD
     WRDLDLALHE MFLFGDIAVK AGSLYTKGVP NNAAAERLVE MMMRMVESDI RSFTHPATQL
     GYMEICVRYS SFFLNHTQLI PGVLESFLQL IHHPIKKVKT RSWYLFQRLV KQLRAHIGNV
     AENVVGALGD LLVIRAELAS EGSDGDDSDD HEGSVDAVFT SQLYLFEAVG IISSTPTVPT
     DKQALYAQSV LSPVFVDMEK NLAPAKANDE RAVQQIHHDI MALGTLAKGF SDWVPGTHSP
     ASLPAAEVSE VFLQASEATL VALESLKGSF SVRTAARFAF SRLIGVLGSR ILPQLPRWID
     GLMTQTSSRD EMALFLRLLD QVIFGFKGEI YGILDALLTP FLQRVFSGIA DPTTGTDDEI
     HLAELKREYI NFLLAVLNND LGAVIISERN QPMFDTVITT IEHFAKDVED YTTAKMAFSL
     LSKMGSSWGG PDITPDGANG ATAQQVALPG FGQFMITRMS PLCWALPATP SFNSKDAQAK
     QVLAEAGGLQ RTIYGKTGME YIEYLRDREL PSMGMGAELV EEFVGALSRL DLKGFRQFFP
     SFIQRLSA