ID   XPOT_BOTFB              Reviewed;        1022 AA.
AC   A6RVT8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=BC1G_04725;
OS   Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS   cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=332648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B05.10;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDN22881.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476860; EDN22881.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001557009.1; XM_001556959.1.
DR   AlphaFoldDB; A6RVT8; -.
DR   SMR; A6RVT8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; RNA-binding; Transport; tRNA processing; tRNA-binding.
FT   CHAIN           1..1022
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343085"
SQ   SEQUENCE   1022 AA;  114179 MW;  1CC234F8B82F5CFE CRC64;
     MDAQIEKAIE IAWDPRSDPN LKEQAVQYLT QVRGDTSSLQ ACLNLFTRAP KAAEVVRLVS
     LDIVNNAIQT QHIDDQSLRG LKEQLHDYVR RTYASGNEVD PPALQNKLTQ TLTFLFSSLY
     KEGWESFIRD FLSFAGHQNG SVDNLSGVVL YLRLLSSIHD EIADLMIARA GEETKRNVEL
     KDLVRARDVH TVAASFQQIL TYWQGNNDAI VEMTLKVIGK WVSWIDISLV VNQDILNLLF
     PLVGRNPNGG EDKVKDAAID CFTEIVAKKM KPSDKIGMIL FLNLGEVVSQ LISSPALHDL
     RNTSSYDTDL AEAVAKLVNN VVSDLVKILE DAKVEPDVRA QAEQLLQTFL PLLLRFFSDE
     YDEICATVIP SLTELNTFLR KAQPLPPAYS AMLTPILNAI IQKMRYDDTS SYADEDELTD
     EAEFQELRKR LQVLQKTIAA VDEALYVDVL SNVIGSTFQR LDEQNGQIDW RDLDLALHEM
     YLFGELTLVN GGLYAKSQPS SIAAERLIVM MSKMVESGIA SFNHPAISLQ YMEICVRYCS
     FFENQTQYIP QVLEQFVSFV HHSHSRVRIR SWYLFHRFVK HLRGQVNVAE TIIQSISDLL
     PLKAEVPREN DDDMSSDDGN HDAADVAFNA QLNLYEAIGC ISSTTSTPIE KQAIYARTIM
     DPLFSDIERN LEQAKSGNAQ ATLQIHHIIF ALGSLAHGFS DWSPGEGKRA GQAPVKEITI
     EFSRAAEAIL FALEALKASF EVRNAARSSF SRLMGVMGVA MLPLLPRWID GLLSQSSSKE
     EIAMFLRLLD QVVFGFKKDI HEVLNSLLTP LFQRVFASLS EPVTGTDDGI QLAELRREYL
     TFVTVILNNE LGSVLVSEQN QAFFDPLIQS VTSLAKTVTN ENGNLAASKI AFNVMTKMAE
     IWGGPTIATP GQPITSPVPS QPTFPGFDSF LIERFHPVCW EVLRDPNFRP LVDAQSKSVL
     NELAGLEQAI YMKTGNMFVE HLQGNFFPSM GVDGSGFIKS MVESPERKGL ATFLQNWMKG
     KA