XPOT_CANAL
ID XPOT_CANAL Reviewed; 1025 AA.
AC Q5A0E2; A0A1D8PRI5; Q3MNU0;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=LOS1; OrderedLocusNames=CAALFM_C704200CA;
GN ORFNames=CaJ7.0486, CaO19.7153;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA Mikami Y.;
RT "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT syntenic analysis against the Saccharomyces cerevisiae genome.";
RL Genetics 170:1525-1537(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AP006852; BAE44920.1; -; Genomic_DNA.
DR EMBL; CP017629; AOW30758.1; -; Genomic_DNA.
DR RefSeq; XP_715202.1; XM_710109.1.
DR AlphaFoldDB; Q5A0E2; -.
DR SMR; Q5A0E2; -.
DR BioGRID; 1226216; 1.
DR STRING; 237561.Q5A0E2; -.
DR GeneID; 3643122; -.
DR KEGG; cal:CAALFM_C704200CA; -.
DR CGD; CAL0000200169; orf19.7153.
DR VEuPathDB; FungiDB:C7_04200C_A; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; Q5A0E2; -.
DR OMA; RFSPLCW; -.
DR OrthoDB; 142520at2759; -.
DR Proteomes; UP000000559; Chromosome 7.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1025
FT /note="Exportin-T"
FT /id="PRO_0000343086"
SQ SEQUENCE 1025 AA; 118464 MW; 18A3A33C1F40B5D5 CRC64;
MEQQIHQAVE IALSGTADPT LKNQAFEFIN HIKSTEEGYK ACVDILIKSS NESINDGLKF
FVYQVIDENI DKLSQEQVFT LNQELFKCLS SYINNNLQDP THLRNKFAQI LAKQFCQVYI
NIYPNFIKDL LELINVSEAT STNPNNLLAI DYYTRVLIGI HSEIGDKYIT RSQEIHNRNN
LLKDAIRTQD MQQMVTSWIQ ILTNPSFAHS EEILNNTLKI VGQYVSWMEI SLFISPEFIN
TVFSFLQNSK LRNTTCETLI DIISKKMAPQ NKLELLSLLN LTEFIGTLNL IEKNKNDDDD
EDEDVEFMEF VAKLLNQIGQ ELLIVLENQS GLLEQVNAQL FKLWPAILGC LNHNYDDVSQ
NVFPFLQQFL TLSKKNPQLY TVDLMSTLLN KLILKMRFDD DDDGVSDEDT QAQFLDFRAK
LKSFQDTIAL LEPQLYLEAI PVIINESIFE TNVDDVNWRK VELGLYQLNG FSDSIRNNVF
QISRNEINQS KPYLIFQEFL IKLINSDLIM KINHPMIQSN FFELIVKHYN FLVSRESNFE
LIIKILQIFT SPLGLFNENE KVRIRSWYLF FRFIKLTKPK LDNEALIESI VVKMQPLLVI
KAELPTKDED DDIVENGNFN NQQYLFETMG LLISLIPNEL SQLKSKLIDL IFQPIFNDLE
KCISIPESQR EPIVILQAHH SLQAIGTLVR GYDYESGLKF LPDVVAKIDN AAQVVLITLE
NFSSHEMIRD ATRFAFARFI PIFKSDNDNN NKNNLIISQH LSKLITIIWS SSNLKISEYS
DFLSFLGQIV HNFRTDDNIY QLLNNFITPL FQKIFQVLQN PVTEDENLRP DIIRDKNSLK
RATLNFISSI VMNHLSSLLI TESNKQELPE IIGKVFEYSY DLSDTTTSKL AIVQLTNFVN
VFGGSGGKLD DKEDKYSENL PPIEGIDEFL INKVINLSFE LPFQKQEFNL NDAQYRLIAQ
EIAILLKSFE LKKHDEFIVV LSNYLLNMGL SQDLCNDFCL NLHNLDLKDF KKYFISFINK
MKSGK
