ID   XPOT_CANGA              Reviewed;        1063 AA.
AC   Q6FNE9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=CAGL0K00473g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CR380957; CAG61206.1; -; Genomic_DNA.
DR   RefSeq; XP_448245.1; XM_448245.1.
DR   AlphaFoldDB; Q6FNE9; -.
DR   SMR; Q6FNE9; -.
DR   STRING; 5478.XP_448245.1; -.
DR   EnsemblFungi; CAG61206; CAG61206; CAGL0K00473g.
DR   GeneID; 2890186; -.
DR   KEGG; cgr:CAGL0K00473g; -.
DR   CGD; CAL0134903; CAGL0K00473g.
DR   VEuPathDB; FungiDB:CAGL0K00473g; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q6FNE9; -.
DR   OMA; RFSPLCW; -.
DR   Proteomes; UP000002428; Chromosome K.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016363; C:nuclear matrix; IEA:EnsemblFungi.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1063
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343087"
SQ   SEQUENCE   1063 AA;  120799 MW;  32DCEF8A65E997A6 CRC64;
     MLARIREVVS IANGSTSSDP ESKRQAIEYF EQLKNDVQST EIFVSLMTDE GSDDLMRFVA
     LQVVCEQIGN GILSQAQLTF VRNAAIELLR SKVNVPNGNL KSTPEYIRTK IAELVTRLFY
     VLYQDQWQSF FPDLTEILQI QSLLENPNEN FSLIGIDYFC RICVFINSEI ADQTFVRSKE
     IQQKNNDLKD QMRVQDVQRL VTIWINTLKS IAPNKQPDIA IMIMACIGSY ISWIDVTLIV
     VPEYVSLIIN YLEFPETKIS CAQCLCEIIS KKMKPVDKLS LLSLLDLTTK VASFDNSVDD
     VDISEQLARL ASAVGTELTI ILEQCNEANP PTEESQQLFS AADQQILLQV IPLILKFMLH
     EYDSVTQQSF QFISQYLAVM KKMFAVGGKA GSVVAVNSKR QSLDSAHEEF LVSLLQVCFK
     KMKIDESCTE ESVDDIEVFC ESIRSKLKVF QDTVAVINPQ IFLTNISACI QNLINSADWR
     DIELVIYQLH NLSESIRNNL FGLPKNQIIN SEPSMIMNNF MRLLLDNSTV FQMDSSYVQI
     SFFELIVRHY QFLSFSGTKD ELSLLNIFCS PFGMFNKREK TRLRTWYLFS RLLKTTKPKF
     PISVLNEIVG KIAPLLPIKV YSLNNDGVEE DSIFESQLYL FEGLGVLIGG NTDSNFEILN
     EILTPLFTDL EACISSSQEQ PQVVLQCHHI LLAIGTLARA VHSGLVPENR VNNALVSKKL
     IHRSLIEKFM NIAEVVLVTF SYFSKHETIR DASRFTFSRL IPILSDDIVP FANKLILLYL
     ESNLKMMEMS DFLSFLGQMI HMFHKEQSCF ELFNNLLGPV ISKVHVLMTQ IEQERNGEEN
     PEWNGTTLNK GHGSNGKNII ITDAFRDKML LKKAYMGFLQ SFVTNNVTSL LLTTQGREVL
     PTILNDVLEY TPQEIQELSV MKLSLNVLVN FVKFFGSGKC TDPEDMYAAS IEKLDGLNEF
     FITKVIPLVF EIPFKPEYKF NVREGSCRVI ASDLSRLLLE LYLQSGGGTS IDTNPCLKYL
     TEVYLPMVQF PPELIMDLVQ NLITSNPKSF EKYFVQLITN FTA