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XPOT_CHAGB
ID   XPOT_CHAGB              Reviewed;        1019 AA.
AC   Q2H6R9;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=CHGG_05646;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CH408031; EAQ89027.1; -; Genomic_DNA.
DR   RefSeq; XP_001221741.1; XM_001221740.1.
DR   AlphaFoldDB; Q2H6R9; -.
DR   SMR; Q2H6R9; -.
DR   STRING; 38033.XP_001221741.1; -.
DR   EnsemblFungi; EAQ89027; EAQ89027; CHGG_05646.
DR   GeneID; 4390917; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q2H6R9; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1019
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343088"
SQ   SEQUENCE   1019 AA;  113739 MW;  2A482E56085B4A8D CRC64;
     MDAQIENAIE IAWDPTSDQA LKGQAFEFLN QLRTDPQAWQ VCIAIFTRTP RTSPVVRLVC
     LEIVNHAVSS QILDGQGLGF LKQSLLEYVG RVYSGDAQDQ VDPAHLQNKL TQTLTYLFVG
     LYKEGWESFI DDFLALAQKE NNLPGVVMYL RILGSIHDEI ADLMLSRSDN EARRNNDLKD
     LIRERDMQKI AQSWQDLLAR YSHQNDGVVE TTLKTIGKWV SWIDIHLVIN QEMISLVLPL
     VGRTHAAGSG DKVRDAAVDT FTEIVAKKMK PSDKAEMITF LNLREIVSQL LASPPLNEWK
     GTPRYDTDLA EAVAKLVNTL VADVVRVLED GKVDNDTRGK AEQLLRDFLP SLLRLFSDEY
     DEVCSTVIPS LTDLLTFLRK VGQLPPTYSE MLPPILNAIV SKMRYDETSN WGNEDEQTDE
     AEFQELRKKL QILQKSVASV DENLCIDLLS NLVANMFSTL EQQGSQMDWR DLDLALHEIY
     LFGELALPNT GLAQKSQPNP LAAERLAVMM SKMVESGIAN YHHPAILLQY MEICTRYYSF
     FEDQQRYIPQ VLENFVRLVH HDHVRIRTRS WYLFHRFVKT LRAQVGNVAK TVIESISDLL
     PIKAEVPGND ADDDMSSDES DHSADAVFSS QLFLYEAIGC ISSTSATPPA DQGLYARSVM
     EPLFSDMSVH IERAKAGDPQ AVLQVHHIIM ALGTLANGFA DAHAAQQGKR PQPHEAVSNE
     FSRAAEAILI ALNELNAIGD VRAACRSAFS RLLGVLGAAV LPQLPQWIEG LLSRSSSNDE
     MAMFLRLLEQ VVYNFKSEIY NILDVLLTPL LQRVFSGLSD PINGTDDEIQ LQELRREFVS
     FVQVILHNEL GGVLVSASNQ GTFESLISSI IDIAKTLTHG NLVASRVAFN VLSRMASQWG
     GPDVATIGEN PMTTGAPAPA IPGFDQFMIE HFHGLCWTVL QDGGFRPNTD AQSRQILNEI
     AGIQQVIYSK TGDAFVNHLQ GVTFPQLGID GTEYLRLLTT SREKKPVVTW LLGLLKGRR
 
 
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