XPOT_CHAGB
ID XPOT_CHAGB Reviewed; 1019 AA.
AC Q2H6R9;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=LOS1; ORFNames=CHGG_05646;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; CH408031; EAQ89027.1; -; Genomic_DNA.
DR RefSeq; XP_001221741.1; XM_001221740.1.
DR AlphaFoldDB; Q2H6R9; -.
DR SMR; Q2H6R9; -.
DR STRING; 38033.XP_001221741.1; -.
DR EnsemblFungi; EAQ89027; EAQ89027; CHGG_05646.
DR GeneID; 4390917; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; Q2H6R9; -.
DR OMA; RFSPLCW; -.
DR OrthoDB; 142520at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1019
FT /note="Exportin-T"
FT /id="PRO_0000343088"
SQ SEQUENCE 1019 AA; 113739 MW; 2A482E56085B4A8D CRC64;
MDAQIENAIE IAWDPTSDQA LKGQAFEFLN QLRTDPQAWQ VCIAIFTRTP RTSPVVRLVC
LEIVNHAVSS QILDGQGLGF LKQSLLEYVG RVYSGDAQDQ VDPAHLQNKL TQTLTYLFVG
LYKEGWESFI DDFLALAQKE NNLPGVVMYL RILGSIHDEI ADLMLSRSDN EARRNNDLKD
LIRERDMQKI AQSWQDLLAR YSHQNDGVVE TTLKTIGKWV SWIDIHLVIN QEMISLVLPL
VGRTHAAGSG DKVRDAAVDT FTEIVAKKMK PSDKAEMITF LNLREIVSQL LASPPLNEWK
GTPRYDTDLA EAVAKLVNTL VADVVRVLED GKVDNDTRGK AEQLLRDFLP SLLRLFSDEY
DEVCSTVIPS LTDLLTFLRK VGQLPPTYSE MLPPILNAIV SKMRYDETSN WGNEDEQTDE
AEFQELRKKL QILQKSVASV DENLCIDLLS NLVANMFSTL EQQGSQMDWR DLDLALHEIY
LFGELALPNT GLAQKSQPNP LAAERLAVMM SKMVESGIAN YHHPAILLQY MEICTRYYSF
FEDQQRYIPQ VLENFVRLVH HDHVRIRTRS WYLFHRFVKT LRAQVGNVAK TVIESISDLL
PIKAEVPGND ADDDMSSDES DHSADAVFSS QLFLYEAIGC ISSTSATPPA DQGLYARSVM
EPLFSDMSVH IERAKAGDPQ AVLQVHHIIM ALGTLANGFA DAHAAQQGKR PQPHEAVSNE
FSRAAEAILI ALNELNAIGD VRAACRSAFS RLLGVLGAAV LPQLPQWIEG LLSRSSSNDE
MAMFLRLLEQ VVYNFKSEIY NILDVLLTPL LQRVFSGLSD PINGTDDEIQ LQELRREFVS
FVQVILHNEL GGVLVSASNQ GTFESLISSI IDIAKTLTHG NLVASRVAFN VLSRMASQWG
GPDVATIGEN PMTTGAPAPA IPGFDQFMIE HFHGLCWTVL QDGGFRPNTD AQSRQILNEI
AGIQQVIYSK TGDAFVNHLQ GVTFPQLGID GTEYLRLLTT SREKKPVVTW LLGLLKGRR