ID   XPOT_COCIM              Reviewed;        1033 AA.
AC   Q1DY99; J3KEJ8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=CIMG_04714;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; GG704914; EAS33690.3; -; Genomic_DNA.
DR   RefSeq; XP_001245273.1; XM_001245272.2.
DR   AlphaFoldDB; Q1DY99; -.
DR   SMR; Q1DY99; -.
DR   STRING; 246410.Q1DY99; -.
DR   PRIDE; Q1DY99; -.
DR   EnsemblFungi; EAS33690; EAS33690; CIMG_04714.
DR   GeneID; 4564964; -.
DR   KEGG; cim:CIMG_04714; -.
DR   VEuPathDB; FungiDB:CIMG_04714; -.
DR   InParanoid; Q1DY99; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1033
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343089"
SQ   SEQUENCE   1033 AA;  116194 MW;  7DDA384E5D0FBA9A CRC64;
     MEEQVANAIE IAGNPSSDQT IKAQAFDYLN QLRADPSGWQ VCLSLFTKTP RRSDVVRHVA
     LEIINSATQT GLVDIQGLSF IKDNLLTYLQ QMYGPDGAAQ SDPSNIQNKI AQTITYLFSA
     LYATEWNTFF DDILRLTYNG PDSGVRDNTL GIIFYLRVIN SIHDEIGDVL VSRSRAEQDR
     ANILKDLIRE RDVQKLVTSW QDILSQWQER NDLIAEMCLR AIGSWVSWIN ISLVVNQTML
     DLLFRQLARV KDVDLHQGGE KVRDAAIDVF TEIVGKKMKP ADKIDMIVYL NLESIVAQLT
     ASPPLHEHRF TSKYDTDLAE TVTKLVNITT VDIVKALDSE DADNATKEKA EALLQAFLPH
     ILRYFSDEYD EICSTAIPCV NELLSYLRKV AKRNPAIIPQ QSAMLLPILK AIIQKMRYDE
     TSSWGTEDDQ MDEMEFQDLR KRLNVLQQII ASTNEQLYMD AVSEVVRATF HNVRQSGGQI
     DWRDLDLALH EMFLFGELAV RCGGLYTKNK PNNPASERLI EMMLMMVESD IRSFRHPATQ
     LQFMEICVRY SSFFEHHARF IPGVLEGFLQ LAHHQMTKVK VRSWYLFHRL VKHLRNYIGN
     VAQTVIAALG DLLTINAEVP VEGPDGDDMS SEDHEGSADA LFNNQLYLFE AIGTICSTSS
     VPLDKQVVYA QSIMNPIFID MERNLGAAKS HDERALLQIH HDIMALGTLA KGFSDWIPGT
     SSPAVPPAPE ISEAFGQVAE ATLVALESLK FSFSIRTAAR AAFSRLIGVR GSHNLPQLPR
     WIDGLLTQTS SKDEMALFLR LLDQVIFGFK TEIYGILDTL LTPFLQRVFA GISEPTTGTD
     DEIQLAELKR EYLNFLLMIL NNDLGTVIIS TTNQPIFETV ITTIEHFAKD VDDFPTAKMA
     FLVLSRMSNL WGGPDVVQPS NPANGTTPSQ SALPGFTQFM ITRFSPLCWA LPMNPSFNPK
     DAQAKQVLGE AAALQKIIYL KTGPEYVRWL RETELPGMGM GPDLVNEYVG SLEMLDIKGF
     RQFFQAFIQR FSA