XPOT_COPC7
ID XPOT_COPC7 Reviewed; 1065 AA.
AC A8NU66;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 2.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=LOS1; ORFNames=CC1G_12568;
OS Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS (Inky cap fungus) (Hormographiella aspergillata).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX NCBI_TaxID=240176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA Zolan M.E., Pukkila P.J.;
RT "Insights into evolution of multicellular fungi from the assembled
RT chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AACS02000004; EAU85429.2; -; Genomic_DNA.
DR RefSeq; XP_001836387.2; XM_001836335.2.
DR AlphaFoldDB; A8NU66; -.
DR SMR; A8NU66; -.
DR STRING; 5346.XP_001836387.2; -.
DR EnsemblFungi; EAU85429; EAU85429; CC1G_12568.
DR GeneID; 6012928; -.
DR KEGG; cci:CC1G_12568; -.
DR VEuPathDB; FungiDB:CC1G_12568; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_0_1; -.
DR InParanoid; A8NU66; -.
DR OMA; RFSPLCW; -.
DR OrthoDB; 142520at2759; -.
DR Proteomes; UP000001861; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1065
FT /note="Exportin-T"
FT /id="PRO_0000343090"
SQ SEQUENCE 1065 AA; 119480 MW; 520331B69DF2C81C CRC64;
MDQEIERVVQ AIAIASEPSQ STLFQEALNY IQGIQENANE TWRLALQIFV ATNGDQGRKY
PPQARFWALR VLEEFLENKF DPLDPETFQT LQQAMMSYIQ SEYVQGPAEA NAPFIRNKFS
HTLTLLFLCT YIDQWPSFFT DLFSLIQPSS QSSSTGLNRH ISLLFFHLVL EISGEVADQM
IKTARTWSAV RHARDGRVRD AVRERDAARI NEAVLTIVAT NVERMNALKE GDGDSQELGN
SIELVDWGIR TFGSYVGWID INLTVTPTTV PLLFKLLADS SLPIRLATSV ALLRIVAKGL
KEPADKLQLF KVLSLGQVLD ALESKTAKQQ RERGDDVDEG EESYREALGK LLNVYGLELT
KLVEDAPTDD IRSDASAALV DLQPVTLRFL ADDYDDTAST VFPLLQAVLG SYKRSRKVSS
GPIDDQKRSF LSALLQVILK KMKWDEEAEP DDVDDDDNGE FEKMRKELRT FMDAILTIDQ
DLVTDEVRKL ALQTISAYQS GTSLKWNDAE LGVYLVYIFG EINKSGGKGR AAFCQTPAVI
DKDKRKVTDY SEFPLTSHGE MLLALVQSGI VSYPNRTVSL QFFETVTRYA DFFKVRKECI
LPALEAMIDK RGLHNENQQF RIRLYYLFYK FIRESRHEIP SQIALTIINS LPDLLSINVQ
LSEPEDPESD PLTEAVKSPV FESQLYLFET IGILTSTLSK DTEEQGNLLL SIVKPFMEEL
LANLQLFRAG SQDLVPVVKV HHIIMALGNI SKGFPDHPAS TTSENYMAPS FKVFAEIAQA
ILVCLEAMNV IKPIRDATRF AFARILATAG PTVTGYIPPL MNHLLAHFEP SELVDFMNFI
SLLIHKLQKD MFEVLDKLIA PLHSHITAIL SQAASGTDEL RWQIETKKAY LNLLVVILNA
RLEGIFTSER NSASFEALLG SLLRIVEDVS DPPSQKLALT FFGRCVTVWG QPAGSPNPEL
GGNLPGFERF IYEQIVPTAF GVVALPSFNP KDGQALMVIH EVASLLQTVC KTRGSEAYDY
FLSAFLPSKG WPAEMALDFT TKLRDLDSKN FRKYFTELIR ASRSS