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XPOT_COPC7
ID   XPOT_COPC7              Reviewed;        1065 AA.
AC   A8NU66;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=CC1G_12568;
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS   (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=240176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA   Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA   Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA   Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA   Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA   Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA   Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AACS02000004; EAU85429.2; -; Genomic_DNA.
DR   RefSeq; XP_001836387.2; XM_001836335.2.
DR   AlphaFoldDB; A8NU66; -.
DR   SMR; A8NU66; -.
DR   STRING; 5346.XP_001836387.2; -.
DR   EnsemblFungi; EAU85429; EAU85429; CC1G_12568.
DR   GeneID; 6012928; -.
DR   KEGG; cci:CC1G_12568; -.
DR   VEuPathDB; FungiDB:CC1G_12568; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_0_1; -.
DR   InParanoid; A8NU66; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1065
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343090"
SQ   SEQUENCE   1065 AA;  119480 MW;  520331B69DF2C81C CRC64;
     MDQEIERVVQ AIAIASEPSQ STLFQEALNY IQGIQENANE TWRLALQIFV ATNGDQGRKY
     PPQARFWALR VLEEFLENKF DPLDPETFQT LQQAMMSYIQ SEYVQGPAEA NAPFIRNKFS
     HTLTLLFLCT YIDQWPSFFT DLFSLIQPSS QSSSTGLNRH ISLLFFHLVL EISGEVADQM
     IKTARTWSAV RHARDGRVRD AVRERDAARI NEAVLTIVAT NVERMNALKE GDGDSQELGN
     SIELVDWGIR TFGSYVGWID INLTVTPTTV PLLFKLLADS SLPIRLATSV ALLRIVAKGL
     KEPADKLQLF KVLSLGQVLD ALESKTAKQQ RERGDDVDEG EESYREALGK LLNVYGLELT
     KLVEDAPTDD IRSDASAALV DLQPVTLRFL ADDYDDTAST VFPLLQAVLG SYKRSRKVSS
     GPIDDQKRSF LSALLQVILK KMKWDEEAEP DDVDDDDNGE FEKMRKELRT FMDAILTIDQ
     DLVTDEVRKL ALQTISAYQS GTSLKWNDAE LGVYLVYIFG EINKSGGKGR AAFCQTPAVI
     DKDKRKVTDY SEFPLTSHGE MLLALVQSGI VSYPNRTVSL QFFETVTRYA DFFKVRKECI
     LPALEAMIDK RGLHNENQQF RIRLYYLFYK FIRESRHEIP SQIALTIINS LPDLLSINVQ
     LSEPEDPESD PLTEAVKSPV FESQLYLFET IGILTSTLSK DTEEQGNLLL SIVKPFMEEL
     LANLQLFRAG SQDLVPVVKV HHIIMALGNI SKGFPDHPAS TTSENYMAPS FKVFAEIAQA
     ILVCLEAMNV IKPIRDATRF AFARILATAG PTVTGYIPPL MNHLLAHFEP SELVDFMNFI
     SLLIHKLQKD MFEVLDKLIA PLHSHITAIL SQAASGTDEL RWQIETKKAY LNLLVVILNA
     RLEGIFTSER NSASFEALLG SLLRIVEDVS DPPSQKLALT FFGRCVTVWG QPAGSPNPEL
     GGNLPGFERF IYEQIVPTAF GVVALPSFNP KDGQALMVIH EVASLLQTVC KTRGSEAYDY
     FLSAFLPSKG WPAEMALDFT TKLRDLDSKN FRKYFTELIR ASRSS
 
 
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