ID   XPOT_CRYNJ              Reviewed;        1139 AA.
AC   P0CN64; Q55S99; Q5KGP6;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=CNE02810;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AE017345; AAW43682.1; -; Genomic_DNA.
DR   RefSeq; XP_570989.1; XM_570989.1.
DR   AlphaFoldDB; P0CN64; -.
DR   SMR; P0CN64; -.
DR   STRING; 5207.AAW43682; -.
DR   PaxDb; P0CN64; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_0_1; -.
DR   InParanoid; P0CN64; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1139
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343091"
FT   REGION          562..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..589
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1139 AA;  125740 MW;  7F623F621382395F CRC64;
     MAATSPHLTS IPQAVRVAAS IDPSIDPGLK QQAIDYLTKV KQLSEETWQL YLQGAGAPGP
     STTGRDGKEK LETDMRMFCL QVVDTVLIQK PEVMGADAVQ GMYEAIVEFI QVEYIGGSCE
     GGQGFLRNKL AFTISQLFLR AFPSHIPTFL HPFFALLSPP TSSPPNLHPQ LLTIRLLLEI
     AQEIHDTTLK TARIMTKERQ ERDGVVRDVI RSSGDDKTAV QGMLGIIEKG LEQMNSGNSS
     DKWAEAVDAT LKTLSAWIPW IDLGVALNPT TLPFYHRLLH QPILSFRTAT AGIYRTLVAK
     GIQDPSSRLQ VLRVLAPVAV IDPLETETRG GKSEEVATFR ASLGVVLSAY GVALIGISDN
     TEVAEQLRNE AEEMMNPALP LLLRFLSDRQ YEVPLSVSPF VSDLLRIYKR MYKPPNPSTK
     AGQAPSPPST LPQLSPERRQ FLASMLDILI RQLAWPEDTE WEAPGNEDEL DEDIAAFKNF
     RGSCRSFIES IAQIDKSLHT EVVARIVIAT LDAYASGGGA AAVPWQQAEL AMHLVYTFGE
     VSKNSTRAAF YELPPEMATK AARNKLRAAQ GSGRTTPSSS DNVDLGPSSN NDRLEYEQFP
     LSPLGQLLTR CMTSGISSYP HPSVTLQYFE IIVRYIEFWK AKPETLPGLF EALLDGQGIH
     NSDEGVRRRC FYLFSKLCKD CRNDTVEGMV SPILDSMRDM MVINAELPPT DTPDEDPLIK
     ATTGKSYVAD QLYLFEASGN LVYLTKADPA KQMALLEAVA GPLLSGLGSG VERARVDEND
     LQAVLQVHHH LMALGHFAKG FPIVPDKLVE LLPYTGPFKQ MAEALLQAIE ILKRRRVVRD
     AARFAFSQFA NAIGTPVAEL VPRFVSAVVT EFEPSELVDF LLFLQLLMHR LQGSTFETMD
     MLLLPLLSRI FTVLQQPVTG TDEAQVHARL KDAYLAFFTS LMNENLDGIF ITDRNKPEFE
     NVLTTLFNLT QDYSDGASQR LAFGFFSRSV IAWGTSPEAA ARPSVFAESA MASQSKMVSG
     GGTAQPNAHA VTQEQRAKQC LPGYENFIYQ RLLPAAFEVP ANSQFNIRGG QLIVHEAAVL
     VRNTVQARGQ EAIDFMLSDL LRRLNCPSDI ANQLIASLTT QQAKDFKKTF FDFIKAMRG