XPOT_DANRE
ID XPOT_DANRE Reviewed; 961 AA.
AC Q5SPJ8;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=tRNA exportin;
GN Name=xpot; ORFNames=si:ch211-286m4.4;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: Mediates the nuclear export of aminoacylated tRNAs.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AL845512; CAI12005.1; -; Genomic_DNA.
DR AlphaFoldDB; Q5SPJ8; -.
DR SMR; Q5SPJ8; -.
DR STRING; 7955.ENSDARP00000076556; -.
DR PaxDb; Q5SPJ8; -.
DR ZFIN; ZDB-GENE-041210-4; xpot.
DR eggNOG; KOG2021; Eukaryota.
DR InParanoid; Q5SPJ8; -.
DR PhylomeDB; Q5SPJ8; -.
DR PRO; PR:Q5SPJ8; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA-binding.
FT CHAIN 1..961
FT /note="Exportin-T"
FT /id="PRO_0000237678"
SQ SEQUENCE 961 AA; 109348 MW; 884476C3731A3498 CRC64;
MDEQALMGLN PNADACYRQR ALAYFEQLKA SLDGWEVCAE ALAKGVYSDD HVKFFCFQVL
EHQIKFRHGS LSAAQQQLIR ETLMKWLQTQ LMNVHPEKPF IRNKAAQVFA LTFVMEYLTL
WPKFFFDVLA LVGLNPNGVD IYLRTLMAID AEVVDRDILH SPEETRRNTL IKDGMREQCI
PALVESWFQI LQTYQHTHSE LTCQCLEVVG AFVSWIDLNL IANDRFVNLL LSHMSMEELR
EAACDCLFEI VNKGMDPVDK TKLVESLCQV LQSAGFFNVE QEEDVDFLAK FSRLVNGMGQ
SLVLSWTKLS KTADEKISAE TLRAVESKVP LMLQLLIHED DDISANIVCF CYDYLHVLKQ
LPALNEQQKS NVEAIMLAVM SKLKYDDEYN FENEGEDEAM FVEYRKQLKM LLDRLAQVSP
ELLLEAVHRV FNATMQSWQT LQFMEVEVSI RLLYMLGEAL PASHGAHFSG DSAKTSTLQA
MMRTLVSCGV SEYQHSSVTL EFFETVVRYD KFFLVEPQHI PAVLMAFLDH RGLRHSSPKV
RSRVAYLFSR FIKTLHKHMN AFIEDILSRI QDLLELAPPE NGFPALLSSD DQLFMFETAG
VLIVNGESPA ERKQGLMRGL LSPLMEAFRM LLEKLPLEPD EERQTALADC LSHAVGFASR
TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPVQRGAL RSAVRSFLHR MIICLEEEVL
PFIPAASQHM LKDCEARDLQ EFIPLISQIT AKFKNQVSPF LQEIFMPLVM SIFEVLSRPA
EENDQTAALE KQMLRRSYFS FIQTIASSSS SQVMASQGAE NIERVLFTII QGAVDFPDPV
AQKTCFIILS RLVELWGGKD GLVGFPDFIY KHIIPACFMA PLKTTFDLSD AQTVLTLSEC
SLTLHMIHLK RGPECLQFLQ EYLPSLHVSP EITQELCQVL QQPDVKVLKN YMKVFFQQAK
L
