ID   XPOT_DEBHA              Reviewed;        1000 AA.
AC   Q6BL58;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=DEHA2F16192g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CR382138; CAG89439.2; -; Genomic_DNA.
DR   RefSeq; XP_461063.2; XM_461063.1.
DR   AlphaFoldDB; Q6BL58; -.
DR   SMR; Q6BL58; -.
DR   STRING; 4959.XP_461063.2; -.
DR   EnsemblFungi; CAG89439; CAG89439; DEHA2F16192g.
DR   GeneID; 2904082; -.
DR   KEGG; dha:DEHA2F16192g; -.
DR   VEuPathDB; FungiDB:DEHA2F16192g; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q6BL58; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1000
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343092"
SQ   SEQUENCE   1000 AA;  115533 MW;  84E132BB36D01567 CRC64;
     MDEQISKAVE IALSGTSDLV LKNQAFEFIN QIKSTEEGYK SCLDILLKSI NSNSPLNQEF
     KFFILQVIDE NITKLNNEQL YELNSDLFQY LNYVINSNIN DPVYLKNKFA GIMGNLFCFT
     YLSINPTFLK DLLALIADNN LIAIDIYSRI IIAVHTEISD KFISRSREVQ DRNNLLKDQI
     RTNDMNLLVD NWQKILRNPE LIQHNNEVLN NFLKIIGYYI NWMEITLFIS NDFINIIFQY
     LNKPDQRNET CLTLIEVISK KMKPLNKLEL ISLLNLTSII NSINNDDDLE FMENIAKLSN
     QVGLELVIVL ESSELELFDS INQQFLNLWP SIFKFLSHEY DDISQQIFPF IQQYLLTCKK
     FNQLASIELL SSLLNKIILK MKFDDDDDGT DDESTEQFNE VRLKLKTFQD TIAILKPELF
     LEAIPIVINE SIFANVSDFD KVNWRNLELG LFELNTFTES LRNNLINLPK QEIGNSKPYV
     LVQEFLIKLI NSDVVLKVDH PKIQLGFFEL IVRHYNFLNT NINNQEVILR ILELFSSPLG
     LFNNSEKVRL RTWYLFFRFV KLTKPTLNNS SFIENLFIKL QPLLVIKAEL PTKDEDNDTV
     ENGNFNNQLN LFESIGLLIS LLSVDISLKV RMIDLIFQPL FNDLENCISN KDKVNQQLIA
     LQAHHSLMAI GTFARGYDYD YNNKYSAEIV GKINNASQVV LITLENFAKF EIIRDAARFS
     FARFIPILNE EINNHLSKLV SIILAANNLK ISELTNFLNF LGQIVHNFQS NDNIYKLLND
     LLSPLLDKIF SLLKYNGENN EYESMPDIIR DKESLKKSYM NFISAIITNH SSSLLITETN
     KQKFPIILES FFVYAYNTSE PTVSKLAITQ LINVVSVMGG HGGKINDPQD KYGESLPPLE
     GVDEYLMNKA VQLSFELPFQ KSEFDLKDAQ YRLVGQEIAS LLKTYQEKRG DEYLTFLSNY
     LTNMGLSSEL MTDFCTNLVK VDQRAFKKYF ITFVTELKGK