XPOT_DICDI
ID XPOT_DICDI Reviewed; 1088 AA.
AC Q54RI9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=tRNA exportin;
GN Name=xpot; ORFNames=DDB_G0283119;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Mediates the nuclear export of aminoacylated tRNAs.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; AAFI02000050; EAL65889.1; -; Genomic_DNA.
DR RefSeq; XP_639247.1; XM_634155.1.
DR AlphaFoldDB; Q54RI9; -.
DR SMR; Q54RI9; -.
DR STRING; 44689.DDB0237585; -.
DR PaxDb; Q54RI9; -.
DR PRIDE; Q54RI9; -.
DR EnsemblProtists; EAL65889; EAL65889; DDB_G0283119.
DR GeneID; 8623933; -.
DR KEGG; ddi:DDB_G0283119; -.
DR dictyBase; DDB_G0283119; xpot.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; Q54RI9; -.
DR OMA; RFSPLCW; -.
DR PhylomeDB; Q54RI9; -.
DR PRO; PR:Q54RI9; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005635; C:nuclear envelope; ISS:dictyBase.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; ISS:dictyBase.
DR GO; GO:0006409; P:tRNA export from nucleus; ISS:dictyBase.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 2.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA-binding.
FT CHAIN 1..1088
FT /note="Exportin-T"
FT /id="PRO_0000328524"
FT REGION 435..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1059..1088
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1088 AA; 125277 MW; DA5B5EA4A5663914 CRC64;
MDEFEKAIIY CFDPNVSEDI KQKALAYTES IKVAPEAWLF CLERLGKTQI VLVKFFCLQV
FQEIILHRYE TLSKTDRLNL RTGLMNWFRL YLVNNQEESA IKNKYAQVMV LLFKQEYLEN
WLTFFDDFLS MLSPGNSSID IFLRICKSID EEVVSFDVHR SPAELAQNTF IKDTMRENAI
TKIVASWYEI LVHHQSPPLI NMTLQNIKTY VGWIDISLIV NDKFIPLFCK YLGVRVVRDE
VCDCFKEIIN KGMDPFAKLT LIQQLEIKNI INFAQLDDQE FNIRVGALIN LTGMEILRSL
ESIQTLQQEG FDKKFQSGEI LLEEMLQLLF RFFNNESNDV SYSVYGLASL YVQKLKNIKV
LNEKQIQHIT LLVQIVRNKM RYKTSRIEED DDESDIKFAD FRKDLSNLFR NIFRICPEMV
GSFIATNIQR IVENKNNNNK NKNTTNSKNG TINNNINKTN NNNNNNTNNI NNNTNNINNN
TTNNNNNNTN KNNVKNANNI KNNNNEDEED DDDMSFSDIE VSIYLLFQMG EGISATSEET
LKSFEKFFGS MVVVLSQSSI SITEHQVVSL IYFETIVRYA KYIPMDEQQY LSSVLKSFLD
ERGIHNKDAL VRSKAGYLLN KLAKYLKVQM FPYINDIIDA LKNHLIISYE IQKEVPFEEQ
LNFYESLGFL IGGANLPIEK EALYIEKILN NPIIKMEEII AKQLYKGDTK ENQFYYTVQL
TQLINVIGTF SKGFSSFNAT NGQLKPDAYC TYKVYFKRSL ESIIQLPSLI PSNEDIKSRT
FFYMHRMVDV LGKDLKPLLV KILPILLDHA TTIDILLEFL VFYNQLISKY KEELFDVINP
TLCPIVDRIY KSLNTTIPPV EHSDAERALN DLKKSYFQLI QALFTHNLAS TLTSTLNLPL
LFQQVFNTVI GGCQASGSHS ESIQKVCFVI LKKMIDDYSP GGPHAVNGFQ SFIYDQVVPL
CFQVPLSDQF NMSDFTSTQI LLEIGKSLRA IAQKYGDEFL TYMNTILLPK LNVSQEVINQ
FIKLLQPSSP IKDFQELLKL FIRQKKGLPI KTSNSNINLN NNNNINNNNN NINNNGHTNG
NGVNKNGH
