XPOT_EMENI
ID XPOT_EMENI Reviewed; 1031 AA.
AC Q5ASE3; C8V9Q1; Q2LD02;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=los1; Synonyms=kapM; ORFNames=AN8787;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Paz L., Fernandez-Martinez J., Espeso E.A.;
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; DQ335590; ABC69304.1; -; Genomic_DNA.
DR EMBL; AACD01000161; EAA60580.1; -; Genomic_DNA.
DR EMBL; BN001303; CBF78020.1; -; Genomic_DNA.
DR RefSeq; XP_682056.1; XM_676964.1.
DR AlphaFoldDB; Q5ASE3; -.
DR SMR; Q5ASE3; -.
DR STRING; 162425.CADANIAP00006275; -.
DR PRIDE; Q5ASE3; -.
DR EnsemblFungi; CBF78020; CBF78020; ANIA_08787.
DR EnsemblFungi; EAA60580; EAA60580; AN8787.2.
DR GeneID; 2868436; -.
DR KEGG; ani:AN8787.2; -.
DR VEuPathDB; FungiDB:AN8787; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; Q5ASE3; -.
DR OMA; RFSPLCW; -.
DR OrthoDB; 142520at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW tRNA processing; tRNA-binding.
FT CHAIN 1..1031
FT /note="Exportin-T"
FT /id="PRO_0000343093"
SQ SEQUENCE 1031 AA; 114948 MW; 5E1ACB34E8596A0D CRC64;
MEEQVANAIE IAGNPTSDST LKAQAFDYLN QLRTDPSGWQ VCLSLFTKDP PQSHFIRHVS
LEVVNSAAQA GLIDLRSLGF VRDRLLAYLR QVYGREGSNP DPPNIQNKIA QTITFLFSAL
YGNGWESFFD DLLSLTHKSP SSTTRDNPLG IIFYLRVINS IHDEIGDVLV SRSRAEQERA
NALKDLIRVR DMQKIASSWQ EILSQWMDGD DLIVEMSLKA VGSWVSWIDI GLVVNQTMLD
LLFQQLGRAQ KAELREGEDK VRDAAVDVFT EIIGKKMKAE DKIDMIAFLN LDNVVGQISS
SPPLYANRFT SKYDTDLAET VAKLVNTTVT DIVRALEQET VSAQCKEKAN GLLQVFLPHI
LRYFSDEYDE VCSTVIPCVS DLLSYLRKMA KSNPSIASQH SSILLPILKA IIQKMRYDET
ASWGDDDDQT DEAEFQELRK RLGTLQQIVA AVDERLYMEA VSEVVATTFE NMRQSGAQLD
WRDLDLALHE MYLFGDSATK SGSLYNKGQP SGPSAERLVE MMLRMVESDI RSFTHPATQL
QYMEICVRYS SFFHTHTHLI PGVLESFLQL AHHPMKKVKT RAWYLFQRLV KQLRAYIDNV
AQTVVEALGD LLVIQAELPS ESSDGDEMSS EDHEGSTDAV FNSQLYLFEA VGIICSIPTI
PADKQVLYAQ SVLSPVFVDM EKNLGSAKSG DARAVLQIHH DIMALGTLAR GFSDWQPGTS
SPATQLPAPE VSEAFSQVSE ATLVALESLK ASFDIRTASR FAFSRLIGVL GSRILPQLPR
WIDGLLTQTS SRDEMALFLR LLDQVIFGFK GEIYNILDAL LMPFLQRVFS GIADPTSGTD
DEIHLAELKR EYLNFLLAVL NNDLGAVIIS ERNQPMFDTV ITTIEHFAKD AEDFTTAKMA
FSVLSRMGSA WGGPDIAPAA SNGPSTSQVA LPGFGQFMIT RFSPLCWALP ATPSFNAKDA
QAKQVLAEAG GLQRTIYSKM GMEYIEYLRD RELPGMGMGA DLVEEYVGTL SRLDLRGFRQ
FFPQFIQRLS A
