ID   XPOT_KLULA              Reviewed;        1063 AA.
AC   Q6CV83;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=KLLA0B14036g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CR382122; CAH02549.1; -; Genomic_DNA.
DR   RefSeq; XP_452156.1; XM_452156.1.
DR   AlphaFoldDB; Q6CV83; -.
DR   SMR; Q6CV83; -.
DR   STRING; 28985.XP_452156.1; -.
DR   EnsemblFungi; CAH02549; CAH02549; KLLA0_B14036g.
DR   GeneID; 2897069; -.
DR   KEGG; kla:KLLA0_B14036g; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q6CV83; -.
DR   OMA; RFSPLCW; -.
DR   Proteomes; UP000000598; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016363; C:nuclear matrix; IEA:EnsemblFungi.
DR   GO; GO:0031267; F:small GTPase binding; IEA:EnsemblFungi.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1063
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343094"
SQ   SEQUENCE   1063 AA;  119717 MW;  0E97239659F8D1DF CRC64;
     MSHIQQAVDI ANSSTAGNDL KKQALDFLQQ LKSSEDAVQV FSQYLQDPVA SDVGRFFALQ
     VLSEQALELP ANHEKLYALQ QSALQFLRTQ LENSSSDGAR VSGVGQGSKG VKSTPPEFVR
     NKVAELFAHL FYNMYGEVNN NMWSSFFVDL IQLVGIASLR DSKSTGVEFN AIGLDLFFRI
     CASINTEIGD QAFVRSKEVQ LKNNELKDYM RVQDVELLSN IWFSALLNCQ QLPVLASLVL
     QCVGSYISWI DINLIVQQSY IGTIYEYLKF PQTKLACGQC LCEIISKKMK PADKLQLLSM
     LNLTDRVVAT GSAEDLDVLE QMAKLTNGVA LELSMVMDQC NDSQELQSVS SAADEQIINV
     VSPLVLKFMA HEYDSVTQQC FSFVTNYLAV MKKLFALGGK PGSAVAVNSK RIPIDPAHLN
     FLKSLGTVCV LKMKIDDSCD SIDDNEEIDE FVENIRSKLK TFQDSIAVIN PELYFDIISD
     NIEQSITEQQ DWRVLELAIY QLHNFAESIR NNLFGVNKTE ISTSKPAQLM EKYMTTLLNH
     PTLFQMNNPL VQISFFELVV RHNNFIQVEN KDLTLLNIFC TPFSMFSGNE RVRLRTWYLF
     TRLIKTSKPK LSTDFLSMLL SKISPLLSIK ASPLAQELDT IFDSQLYLFE GTGVLIGANV
     NNEYEILDGV LTPLFADLEQ CISAQVKNPQ VVLQTHHILM AIGTVARGVH SGLVPDNQVN
     NAKVSERVIC KSLIEKFSNI AEVILVTFSY FNKFETIRDA ARFSFSRLIP ILNNQIIPFA
     SRLISIFLNS DLKPLEMGDF IGFLGQMIHM FKDDDNCYQL FNNLFTPVVE KVFTLETQLE
     QESSTSSESK SSNGKNVIVT DSFREKINLK KSYYGLLATF VSNNCTSLLL TESNKNILPR
     VLTDLLSYTA EEIHETSTMK LSINVLVNFI NFFGTGICTD PKDRNAINVN KLDGLNEFFI
     TTSIPLLFEI PFKPEYEFNI QDGGCRVIAC DLSRLLKALY NINNSSTNNN INENACVKYL
     TEIYFPQIQF PQSLVVEFIN ALGTLDAKQF EKYFVQFITN MKQ