ID   XPOT_LACBS              Reviewed;        1066 AA.
AC   B0DAD3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=LACBIDRAFT_249920;
OS   Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver)
OS   (Laccaria laccata var. bicolor).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomataceae; Laccaria.
OX   NCBI_TaxID=486041;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S238N-H82 / ATCC MYA-4686;
RX   PubMed=18322534; DOI=10.1038/nature06556;
RA   Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F.,
RA   Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J.,
RA   Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.,
RA   Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A.,
RA   DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P.,
RA   Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P.,
RA   Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R.,
RA   Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H.,
RA   Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M.,
RA   Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U.,
RA   Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J.,
RA   Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A.,
RA   Tuskan G., Grigoriev I.V.;
RT   "The genome of Laccaria bicolor provides insights into mycorrhizal
RT   symbiosis.";
RL   Nature 452:88-92(2008).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; DS547101; EDR08512.1; -; Genomic_DNA.
DR   RefSeq; XP_001880737.1; XM_001880702.1.
DR   AlphaFoldDB; B0DAD3; -.
DR   SMR; B0DAD3; -.
DR   STRING; 486041.B0DAD3; -.
DR   EnsemblFungi; EDR08512; EDR08512; LACBIDRAFT_249920.
DR   GeneID; 6076358; -.
DR   KEGG; lbc:LACBIDRAFT_249920; -.
DR   HOGENOM; CLU_004414_0_0_1; -.
DR   InParanoid; B0DAD3; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001194; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1066
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343095"
SQ   SEQUENCE   1066 AA;  120178 MW;  B1BA999D396A07CD CRC64;
     MEQEIDQIVQ AITIASDPTQ ASLYQQALAY ISTIQQNANE TWRLALHIFV DQNTEGHRKH
     PAQARFFALR VLDEFFDNRF EPLDHESFQA IHQALTAYIQ SEYVVGSAEA DASFLRNKFS
     HTLTLFFLCT YIDQWPSFFT DLFTLIRPTE SATRSNFNRH ISLLFFHIVL EISGEVADQI
     IKSARPYNAA RHARDARVRD AVRDRDAARI NAAVLTIVVE GAEQMANLHK SETSSRGPRE
     LEGAVEVVDW GIRTFGSYVG WIDINLTVTP TTVPLLFNLL ADSSLPIRLA TSVSLLRIVS
     KGLKEPGDKL QLLKVLSLGQ VLDALEAKTR AQQIEREESY REALGKLLNV LGLELAKLVD
     DCSDEDIRAE ASTYITQIQP VMLRFMADEY DDTCSTVFPL LQNILTTYKR HRKISSNPLD
     ESKRSFLASL LQVLLAKMKW EEDADPEDAD EDDNAEFDKM RKELRTFLDS ILAIDQVLVT
     DAVKTLALDT ITAFKNGVSI KWNDAELGVY LVFIFGEINK SMTRIAGGKG RAAFCQAPAV
     VDKDKRKATD YSDYPLTTHG EMLLALVQSG VASFPHRTVS LQFFETASRY TDFFKIRKDC
     IIPTLEAMID TRGLHNENLN FRSRLFYLFH RFIKESRNEI PPHISGNIID SMRDLLLIEV
     EIPAAEDTEI DPLSEAIKNS QFDSQLYLFE TAGILTSLLC KTPTQQTAML LSLVKPLMDD
     LSVSLQAFSK GGQDLLPIVK VHHIIMALGN IAKGFPDYPT SIPEGHILPP LEIFTEVAQA
     ILVCLEAMNV YKPIRDATRF AFARILATTG PTVTSYIPQL MGNLLAHFEP TELVDFMNFI
     GLLIHKLQKD MFDVLDQLIG PLSAHITSLL TQPVSGTDEH RAHIETKRAY LALLNNIMAS
     KLDGIFTSER NSSNFEVLLE SMQRLAEDVS DPASEKTAIM FLNRSVTVWG QPSSSENGRE
     TGHGLPGFER FIYERLVQTC FRVPSLPQFN LKDGQMMVVL HEIANLLQVI CKIRGHEAYN
     FFISVFLPSQ NWPSETALDF MTKLRDLDGK GFRKYFTELI RSSRTS