ID   XPOT_LODEL              Reviewed;         988 AA.
AC   A5E7I7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=LELG_05576;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CH981533; EDK47395.1; -; Genomic_DNA.
DR   RefSeq; XP_001523350.1; XM_001523300.1.
DR   AlphaFoldDB; A5E7I7; -.
DR   SMR; A5E7I7; -.
DR   STRING; 379508.A5E7I7; -.
DR   EnsemblFungi; EDK47395; EDK47395; LELG_05576.
DR   GeneID; 5230324; -.
DR   KEGG; lel:LELG_05576; -.
DR   VEuPathDB; FungiDB:LELG_05576; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; A5E7I7; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..988
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343096"
SQ   SEQUENCE   988 AA;  113074 MW;  F7982E30FC95ABD3 CRC64;
     MESQILNAIE IALDGSADQK LQVQAYEFLN EVKGSKSGYD TALKLLSSSP SNTLISQLKF
     FLYQVLEENA ENLDPEDCLQ LCQTLFKMLS EFIVNDLKDE AFLRNKLAQV FAKVFTQVYI
     STVPDFLTNL LATTQTNSQL ALDYYTRILM SIHMEIGDKY ITRSPALSER NMTLKDAIRS
     RDMSALVTSW FNILENTNNL DEVLDNTLNI IAQYVDWMEI GLFVSPQSIN TIIGYLSREN
     ERNSTCETLI HILLKKMPAQ NKLELVSLLN LTNVISSIDL SDDLEFVERI AKLANQIGEE
     LLIVLGNQPS LLDQVNEQLL KLWPIVLTFL GHEYDDVSQS VFPFIQQFLG ACKKHSQLYS
     VELLSTLLNK TISKMEYDEE DDDSDEETER QFAEFRARLK LFQDGIASLV PDLYIEAVPI
     IINQSLFEGD KPWNKLELGM FELSNFSESL KNNVINAPKA KISESKPYLM FQEFLVKLIN
     SPFIIKVNHP LIQSSFFELV VKHYSFLNSH ENRKELVFKI IEIFTSPLGL LNSNDKVRLR
     SWYLFFRFMK LTKPKMDNEA LIEDIVLKMQ PLLVIKAELP TRDEDDDVVE NGNFNNQQYL
     FETMGLLISL IPNEYVSLKV KLVQAMFQPI FNDLEKCISI ANKEPIIVLQ AHHSLMALGT
     IVRGYDYETN LKFPPEVVEK VDNAAQVVLI TLENFSKSES VRDASRFAFA RFIPILNSTI
     ISGHLTKLIT IIWSAPNLKI SEISDFLSFL GQIAHTYRTD ENIYQLLNNF LSPLFKKVFE
     VLDLPVTEDE SLRPDISRDK NFLKKAILNF INAIIINHLP SLLVTESNKN ELATVVSKLF
     EYAYDISDTA VSKLAIVQLI NLVNVFGQEG KISDEQDKYG QSLPPVEGID NFLMEKVVNL
     SFELPFRKQE FVLGDAQYRL IAQDIALLLK TFQQKKGEQF VEYLSVYLTN MGLGQDMTND
     FCSNLINLDL KDYKKYFVTF VSQMKGEK