ID   XPOT_MALGO              Reviewed;        1090 AA.
AC   A8Q513;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=MGL_2695;
OS   Malassezia globosa (strain ATCC MYA-4612 / CBS 7966) (Dandruff-associated
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC   Malasseziomycetes; Malasseziales; Malasseziaceae; Malassezia.
OX   NCBI_TaxID=425265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4612 / CBS 7966;
RX   PubMed=18000048; DOI=10.1073/pnas.0706756104;
RA   Xu J., Saunders C.W., Hu P., Grant R.A., Boekhout T., Kuramae E.E.,
RA   Kronstad J.W., DeAngelis Y.M., Reeder N.L., Johnstone K.R., Leland M.,
RA   Fieno A.M., Begley W.M., Sun Y., Lacey M.P., Chaudhary T., Keough T.,
RA   Chu L., Sears R., Yuan B., Dawson T.L. Jr.;
RT   "Dandruff-associated Malassezia genomes reveal convergent and divergent
RT   virulence traits shared with plant and human fungal pathogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:18730-18735(2007).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EDP43099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AAYY01000009; EDP43099.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001730313.1; XM_001730261.1.
DR   AlphaFoldDB; A8Q513; -.
DR   SMR; A8Q513; -.
DR   STRING; 425265.A8Q513; -.
DR   EnsemblFungi; EDP43099; EDP43099; MGL_2695.
DR   GeneID; 5854618; -.
DR   KEGG; mgl:MGL_2695; -.
DR   InParanoid; A8Q513; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000008837; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1090
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343098"
SQ   SEQUENCE   1090 AA;  119924 MW;  E210D5DAC9F2B699 CRC64;
     MASTPEEQLV KAVEIASNAA AVSDADLVAQ ALAFLEQLKQ VTHESWSVGW TIWTARTEDG
     SAPKYEHAPR LFGLNLVDEF LDKHIHSVSE AVNALAFLQE SALAYLQSEF VHGHGEQGIV
     FMKNKLAQTL SLLMVQTYSL SSSYSFLSAA LSLCTTHPSA DTDSGLNVMA TDLMMRVLHD
     LSLSLGSDAT LRSVRGKDRL QRDALVRDEI RTHHAASMAE LMWRVIQDSL RTLQIPDAGG
     TTTASSPQQL TAGNAGPLAS VAMAVVGDYA SWIDISLVVT IDTVQILYNA LDAQHMPLRY
     ATADTLCEIV SKGMKPADKL GLIECLRLDT VLTQLELSTR GQGEAQTELR EHLARLVNAL
     CTELCKIAED TTGAQADTRD AAHTKLLVFL QPALSFLADE YDEPAEQVLP CLHLVLSLYK
     KTKRQNENMG LPSLSAPTLE FVTQLIALAL QKLKFDADID WQDSSLVGGP ADADADESED
     DDEQLVRFYE LRKQLQVILG AIAAIDEPLV SNTIQTLVAN TLGSVASPTE LPWEQAEVCL
     YAAFSCGEIL SSIRGNKIGL GAHSYVQIPS EPGKAPARNV RQSLSVYQAL PPNTLGEILQ
     LLFRSRIGDH AHPVVQLQYF ECVVRYASCF VLWSDLLPNA LEAFLDQRGL CQPHLGMRRR
     LNYLFYRFVR DTRTAIPSEI VPRLLESLPL AVNAVLPEVP PEEDVLVKAT EKASAFDSQL
     YLFESCGLLM SQLGHVPETQ VMLFKAMTQP LVEQLLQVVQ AFGGDPDNLQ LVLQVHHLIL
     ALSTITKGFP DYDMNRPTEP AWIEELKPIT EQILLALTAL NRFSIVREAA RGAFARIVTS
     AGPAVLPYIP TLIHALVHQV TEAELVDLLN FFGLITHKYK DNVRSVMDDV FGVLVTRIFS
     FLNQGIQGTD DMVRRSDTER AYFGLVHALL SAGLDDVLVS EKNQGQLESV LQSHVYYASH
     GEPVTQRAAI SALAWLVQLW ARPSEKAIPG FEQFVYDAIL PLVFQVPTKP SFDQSDAQAQ
     LVLSELAGLL KSLHTARGDE FLHYLSSIYL PGVQCPPELA VELTKNIQSL DVKPLKRYLD
     TFIAQSRGGA