ID   XPOT_NEOFI              Reviewed;        1037 AA.
AC   A1DEK2;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=NFIA_077460;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAW17809.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; DS027696; EAW17809.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001259706.1; XM_001259705.1.
DR   AlphaFoldDB; A1DEK2; -.
DR   SMR; A1DEK2; -.
DR   STRING; 36630.CADNFIAP00008432; -.
DR   EnsemblFungi; EAW17809; EAW17809; NFIA_077460.
DR   GeneID; 4586368; -.
DR   KEGG; nfi:NFIA_077460; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1037
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343099"
SQ   SEQUENCE   1037 AA;  115965 MW;  73181DEE15EC4ADA CRC64;
     MEEQVANAIE IASNPSADPA LKTQAFEFVN QLRSDPSGWQ VCLSLFTQTP QRSGIVRHVA
     LEVVNSAAQG GLIDLQALAY VKDGLLAYLR QVYGQDAGAS DPPNIQNKIA QTITFLFSAL
     YASGWESFFD DLLSLTHKSP SSTTRDNASG IIFYLRVINS IHDEIGDVLV SRSRNEQDKA
     NALKDLIRQR DMQKITSSWQ QILSEWRDGN DVIVEMCLKA VGSWVSWIDI GLVVNQTMLD
     LLFQQLGRAQ KEDLRQGEEK VRDAAVDVFT EIIGKKMKPE DKIDMIIFLN LDTIVSQLSN
     SPPLHGNRFT FKYDTDLAET VAKLVNITVI DIVRALEQEG VSAECKEKAN GLLQAFLPHI
     LRYFSDEYDE VCSTVIPCVS DLLTYLRRIA KVNPALASQH SSILLPILKA IIAKMRYDET
     SSWGEEDEQT DEAEFQELRK RLGILQQMIA SVNEQLYMEA VSEMVATTFE NLRQSGSQMD
     WRDLDLALHE MFLFGDLAVK AGSLYTKSNP NNQAAERLIE MMLRMVESDI RSFTHPATQL
     QYMEICVRYS SFFHHHTHLI PGVLENFLQL VHHPIKKVKT RSWYLFQRLV KQLRQYVGNV
     AQTVVEALGD LLVIRAELPS EVSEGDEMSS EDHDLADAIF NSQLYLFEAV GIICSTPTVS
     PDKQVLYAQA VLNPIFLDME KNLEAAKSQD ERAILQIHHD IMALGTLARG FSDWMPGTNT
     PATLPAPEVS AAFNQVAEAT LVALESLKSS FNVRTAARFA FSRLIGVLGS RILPQLPRWI
     DGLLTQTSSR DEMALFLRLL DQVIFGFKGE IYSILDTLLT PFLQRVFSGI ADPTTGTDDE
     IQLAELKREY LNFLLAVLNN DLGAVIISER NQPIFETVIS TIEHFSKDID DFTTAKMAFS
     VLSKMSSSWG GPDVIAEASN GAPLAQAPLP GFGQFMITRF SPLCWALPST PSFNSKDAQA
     KQVLAEAGGL QRTIYAKTGM EYLTYLRDRE LPGMGMGAEL IEEFVGALSR LDLKGFRQFF
     PVCLSNFHHS LDLNMNN