ID   XPOT_NEUCR              Reviewed;        1026 AA.
AC   Q7RWV9; U9W377;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=NCU11169;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CM002238; ESA43277.1; -; Genomic_DNA.
DR   RefSeq; XP_011393760.1; XM_011395458.1.
DR   AlphaFoldDB; Q7RWV9; -.
DR   SMR; Q7RWV9; -.
DR   STRING; 5141.EFNCRP00000000410; -.
DR   EnsemblFungi; ESA43277; ESA43277; NCU00134.
DR   GeneID; 23568336; -.
DR   KEGG; ncr:NCU00134; -.
DR   VEuPathDB; FungiDB:NCU00134; -.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q7RWV9; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1026
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343100"
SQ   SEQUENCE   1026 AA;  114812 MW;  E647A888C885AE30 CRC64;
     MDAQFEKAIE IAFDPRSSHA LKSQALEFLN QVRTDVQAWR ICAALFTRSP RASDIVRHVS
     LEMVNNAVHS QGLDAPDLAF VKNSLLDYIT RTYGPNAQDQ ADPANVQNKL TQTLTYLFVA
     LYGEGWETFF DDFLALTSSQ NGASRDNLSG VMLYLRILSS VHDEIADLMI SRQGNESKRN
     NDLKDLIRER HMQKIAMSWQ DILAQWTNKH DGVVELTLKV IGKWVSWIDI SLVVSQDMQN
     LILPLVGRVN NTSNNIDTVR DTAIDTLTEI VAKKMGPSHK MELISFLNLG GIITELLASQ
     GLHEFKGTSR YDNDLAEVVA KLLNTIMTDV VRVLEDNKVD AETRAKAERH LQDFLPALLR
     LFSDEFDEVC STVIPSLTDL LTFLRRVGTL PDSYSQMLRP ILSAIVAKMR YDETSSWGTE
     DGESDEAEFQ ELRKRLQILQ KSVAAVDQTL YIEFLSNLVG NMFATLEQQG PQMDWRDLDL
     ALHEIYLFGE LALPNAGLAH KSEPNVVATE RLAVMMSKMV ESGIANFPHP AILLQYMEIC
     VRYHAFFESH HQYIAPVLEN FVHLIHHEHP RVRTRSWYLF LRFVKQLRAQ VGNVAKTVIQ
     SISDLLPIKA EVPSTEAEDD MSSDESDHSA DAIFNGQLYL FEAIGCISST STTPETDQAL
     YARSVMEPLF SDMSVHLPRA KSGDAQAILQ IHHIIMALGT LANGFADPNQ SQNPNNQRTP
     PQAVSAEFSR ASEAILVALN ELNTNGEIRA ACRSAFSRLL GVLGATILPQ LPQWIEGLLS
     QSSSKDEMAF FLRLLEQIVY NFKGEIYNIL DLLLTPLLQR VFAGLSEPIN GTDDEIQLQE
     LRREYVSFVQ VILINELGGV LVSTSNQGVF ESLVNSIMTI AKTIVHGNIV ASRISFNVLA
     RMAQQWGGPD VATIGENPTA NGVPAPAFPG FDQFMLTQFH AACWEVMQDI NFRPYADAQT
     RQILNEITGL EQIIYLKTGE KFISHCQTVT FPAVGMGAED FLRALTSSTD RKAVMAYLQQ
     LLKSRR