ID   XPOT_PICGU              Reviewed;         986 AA.
AC   A5DLM5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=PGUG_04176;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CH408159; EDK40078.2; -; Genomic_DNA.
DR   RefSeq; XP_001483447.1; XM_001483397.1.
DR   AlphaFoldDB; A5DLM5; -.
DR   SMR; A5DLM5; -.
DR   STRING; 4929.XP_001483447.1; -.
DR   EnsemblFungi; EDK40078; EDK40078; PGUG_04176.
DR   GeneID; 5125107; -.
DR   KEGG; pgu:PGUG_04176; -.
DR   VEuPathDB; FungiDB:PGUG_04176; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; A5DLM5; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..986
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343102"
SQ   SEQUENCE   986 AA;  110643 MW;  4B8C9EC542CE189F CRC64;
     METQIQQAVE IALSGTADPA LKSQAYEFID KIKTSENGLQ SCVTILLSSS SVTSEALRFF
     VLQVVEENIP KVSNERLYSI NNSLLQFLRE NYIVNHQSYP IYLRNKLASV MATLFCHVYL
     TINPQFLVQL LEYSSSPPGT DIYVRIHLAI HAEIGDKLIA RSPQQQERNN ALKDSIRAND
     MQRLVQSWRS ILENAEAHTS DTLTNTVRVV GCYVSWMEIS LFVVPDFIGV IFSYLRKPDQ
     RTAACETVAE IISKKMKPEN KLQLLALLNI TDVVGSLAQD SDDLEFTESV ARLANQVGLE
     LLIVFEAQSD STSEVMNQLM GLWPSVLGFL THEFDDVAQL VFPYIQQYLL ACKKQKTLIN
     NDLLKELFAK CIIKMKFDGD DDGLDDDSAA QFEEIRAKLK TFQDTIAILV PNLYLDLVPA
     VISESLFSNK PDWQTSELGL YQLSNFADGV RNNLVGVPKK ELTTSKAFAV LRELFIQLID
     SSVVSSSGHP RVQLSFFELV VRHYTFVASG TNPDPILKVF GSSVGMFNES EKVRLRSWYL
     FFRFIKLVKP QMSNPSFVEE ILLKLQPLLV IKAELPVRDE DDDVVDNGSF SSQLYLFEAL
     GLLIGLMSVD DSTKLRMVDA IFSSLFSSLE SCVAASESER NSQPIIPLQA HHALMAIGTF
     VRGYDDSNVK SGQVMVDKVD NAAQVVVITL SNFAKHEQVR EASRFAFARF VPILRDRCTV
     HLSKLISLII NASNLTVTEL SDFLSFLGQL VHTFKGNANV YQLLNDLLTP VVEKIFSLLK
     YNGENNDFDT MPDVIRDKNG LKKAYMNLLS AIIMNNSSSL LVTESNKAKL PEILSSLFEY
     SYDLADTTVA KLAVTQLINF VTVLGGSGGK INDPNDTYGE SLPAIEGVDE YLIEKSMHLC
     FELPFQKTEF DLKDAQFRLI AQEISQLIKI CYDRKGDTYL QYLSTYLTTM GMAPELMNDF
     GSSVVKLDNR AFKKYFITFV SQLKSA