ID   XPOT_PICST              Reviewed;         992 AA.
AC   A3LWK3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=PICST_89506;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000499; ABN67295.2; -; Genomic_DNA.
DR   RefSeq; XP_001385324.2; XM_001385287.1.
DR   AlphaFoldDB; A3LWK3; -.
DR   SMR; A3LWK3; -.
DR   STRING; 4924.XP_001385324.2; -.
DR   EnsemblFungi; ABN67295; ABN67295; PICST_89506.
DR   GeneID; 4839207; -.
DR   KEGG; pic:PICST_89506; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; A3LWK3; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000002258; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..992
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343103"
SQ   SEQUENCE   992 AA;  113774 MW;  EA64A0E3353EA691 CRC64;
     MEQQIHQAVE IAMSGTADPN LKNQAFAFIN QIKSTEDGYK SCVDILVKSG AQPVNEGLKF
     FIFQVVDENI EKLSSEQLYS LNDQLFKTLS SYISNDVSDP IYLRNKFSQL FAKIFCYVYL
     NIYPNFFKSL FELISSNKQI ALDYYTRIVI AIHYEIGDKF IARSRELQDR NNLLKDAIRL
     NDMNALVSSW GKILQVPSNS SEVLNNQLKI VGQYINWMEI GLFISNDYMR SIFQYLNKEH
     QRNETCMTLI EIISKKMKPS NKLELVGILD ITNIINSIDL SENDDLEFVE NIAKLINQVG
     QELLIVLENE PTLFSSINAQ LAKLWPLIFS SLGHEYDDVS QHVFPFIQQY LLLCKKSPEL
     GSLDLLSTLL NKIIIKMKFD DDANGVDDDD ETEQFSEIRS KLKNFQDTIA VLKPDLYVEA
     ITIVINESLF GGDKNWRKIE LGLFELNNFS ESLRNNLINL PKSEITNSKP FQIFQEFLVK
     LINSDLIINV NHPKIQIGFF DIVVKHYNFL NAQSSQQSLI LRILEIFTSP LGLFNENEKV
     RLRSWYSFFR FVKLTKPSLN NTAFVENVVI KLQPLLVIKA ELPTTDEDDD VVENGNFSSQ
     LYLYESIGLL ISLLSTDLMN HKIKFIDLVF QPLFNDLENC VSSSEQVKLN QPLISMQAHH
     CLMALGTFAR GYDHDFQNKY SEEIRGKINN AAQVVLITLE NFPKNELIRD AARFSFARFI
     PILKNQINIH LAKFVTLVLA ANNLKISELT DFLSFLGQIV HNYKDDDNIY QLLNNLLTPL
     IKKIFELSSN SGEDALIPDI IRDKYQLKKA YMTFLSAIFL NHSASLFVTE TNKQEFAEVV
     TSLLEYAYDL SETSVSKLAI TQLINVVNFF GNGGKIHDPE DKYANNLPPV EGIDAFLMSR
     VTQLSFELPF QKQEFDLKDA QYRLIGQEIS LLLKSYQQRG GDEFLSYLSN YLTNMGLSQS
     LMNDFGSNLV KLDARNFKKY FITFVTQLKG NK