ID   XPOT_PODAN              Reviewed;        1014 AA.
AC   B2AXG6; A0A090CXI0;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=Pa_7_10490; ORFNames=PODANS_7_10490;
OS   Podospora anserina (strain S / ATCC MYA-4624 / DSM 980 / FGSC 10383)
OS   (Pleurage anserina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora;
OC   Podospora anserina.
OX   NCBI_TaxID=515849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=18460219; DOI=10.1186/gb-2008-9-5-r77;
RA   Espagne E., Lespinet O., Malagnac F., Da Silva C., Jaillon O., Porcel B.M.,
RA   Couloux A., Aury J.-M., Segurens B., Poulain J., Anthouard V.,
RA   Grossetete S., Khalili H., Coppin E., Dequard-Chablat M., Picard M.,
RA   Contamine V., Arnaise S., Bourdais A., Berteaux-Lecellier V., Gautheret D.,
RA   de Vries R.P., Battaglia E., Coutinho P.M., Danchin E.G.J., Henrissat B.,
RA   El Khoury R., Sainsard-Chanet A., Boivin A., Pinan-Lucarre B., Sellem C.H.,
RA   Debuchy R., Wincker P., Weissenbach J., Silar P.;
RT   "The genome sequence of the model ascomycete fungus Podospora anserina.";
RL   Genome Biol. 9:R77.1-R77.22(2008).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=S / ATCC MYA-4624 / DSM 980 / FGSC 10383;
RX   PubMed=24558260; DOI=10.1534/genetics.113.159988;
RA   Grognet P., Bidard F., Kuchly C., Tong L.C.H., Coppin E., Benkhali J.A.,
RA   Couloux A., Wincker P., Debuchy R., Silar P.;
RT   "Maintaining two mating types: Structure of the mating type locus and its
RT   role in heterokaryosis in Podospora anserina.";
RL   Genetics 197:421-432(2014).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP69090.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CU633900; CAP69090.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; FO904942; CDP32567.1; -; Genomic_DNA.
DR   RefSeq; XP_001908417.1; XM_001908382.1.
DR   AlphaFoldDB; B2AXG6; -.
DR   SMR; B2AXG6; -.
DR   STRING; 5145.XP_001908417.1; -.
DR   EnsemblFungi; CAP69090; CAP69090; PODANS_7_10490.
DR   GeneID; 6192513; -.
DR   KEGG; pan:PODANSg5452; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   OrthoDB; 142520at2759; -.
DR   Proteomes; UP000001197; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1014
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343104"
SQ   SEQUENCE   1014 AA;  113665 MW;  87A5DE00383F6C87 CRC64;
     MDAQIENAIE VAWNPSSSQE LKGQAFEYLN QLRVDPQAWQ VCIGLFTRSP PASEVVRLVS
     LEIINNAVHS EALDAASLVY LKQSLLEYIG RTYTSNTQSQ VDPAHLQNKL TQTLTYLFVF
     LYREHWSSFV QDFYAIAQND NLPGVILYLR ILSSIHDEIA DLMLSRQEQE AKRNSDLKDL
     IRERDMAKIA TSWTDILSRY SNQHDGVVEM TLKIIGKWVS WIDISLVINQ QMLGLLLPLV
     GRSNASGGED KVRDIAVDTF TEIVSKKMKA SDKIEMINFL QLREIITELL ASPPLNEWKG
     TSQYDTDLAE VVAKLVNAIM SDIVRVLEDG KVDNDTRAKA EQLLQYFLPS LLRLFSDEYD
     EVCSTVIPSL TDLLTFLRKV RTLPATYAEM LPPILNAIVL KMRYDETSNW GLEDEQTDEA
     EFLELRKRLQ ILQKSVAAVD ENLCMEFMSN LVGNMFSTLQ QQGSQMDWRD LDLALHEMYL
     FGELALPNMG LAAKSQPNPV AAERLALMMS KMVDSGIANY AHPAILLQYM EICVRYHSFF
     ESHQNYIPRV LENFVRLVHH EHVRVRTRSW YLFLRFVKTL RAQVGNVAKT VIESISDLLP
     IKAEVPSNDA DDDMSSDESD HSADAVFNGQ LYLFEAVGCV SATSATPVAD QALYARSVME
     PLFSDMSVHL ERAKAGDAQA ILQIHHIIMA LGTLANGFAD TPLGHTKARA QPAQEISAEF
     TRASEAILIA LNQLNTSDEI RAACRSAFSR LLGVLGSAVL PQLPQWIEGL LSRSSSKDEM
     AMFLRLLEQI VYNFKGEISN ILDLLLTPLL QRVFGGLSEP INGTDDEIQL QELRREYVSF
     VQVIFMNDLG GVLVSAANQG NFESLVSSIF SVAKNLNHGN LVASRIAFNV LSRMITQWGG
     PDIITPGENP VATGPPSPTI PGFEQFMLSQ FHGVCWDVLQ DGGFRPSSDA TSRQILNEIA
     GIQQAIWMKT ADLYINHVQN QLGQDSNDFL RTLTTTTARK PLVDWFLALL KGRK