XPOT_SCHPO
ID XPOT_SCHPO Reviewed; 978 AA.
AC O94258;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Exportin-T;
DE AltName: Full=Exportin(tRNA);
DE AltName: Full=Karyopherin-beta;
DE AltName: Full=tRNA exportin;
GN Name=los1; ORFNames=SPBP8B7.09c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex. Involved in pre-tRNA
CC splicing, probably by affecting the interaction of pre-tRNA with
CC splicing endonuclease (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC O94258; P32835: GSP1; Xeno; NbExp=2; IntAct=EBI-15799183, EBI-7926;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR EMBL; CU329671; CAA21794.1; -; Genomic_DNA.
DR PIR; T40803; T40803.
DR RefSeq; NP_596516.1; NM_001022437.2.
DR PDB; 3IBV; X-ray; 3.10 A; A/B=1-978.
DR PDB; 3ICQ; X-ray; 3.20 A; T/U=1-978.
DR PDBsum; 3IBV; -.
DR PDBsum; 3ICQ; -.
DR AlphaFoldDB; O94258; -.
DR SMR; O94258; -.
DR BioGRID; 277823; 26.
DR DIP; DIP-59297N; -.
DR IntAct; O94258; 1.
DR STRING; 4896.SPBP8B7.09c.1; -.
DR iPTMnet; O94258; -.
DR MaxQB; O94258; -.
DR PaxDb; O94258; -.
DR EnsemblFungi; SPBP8B7.09c.1; SPBP8B7.09c.1:pep; SPBP8B7.09c.
DR GeneID; 2541311; -.
DR KEGG; spo:SPBP8B7.09c; -.
DR PomBase; SPBP8B7.09c; los1.
DR VEuPathDB; FungiDB:SPBP8B7.09c; -.
DR eggNOG; KOG2021; Eukaryota.
DR HOGENOM; CLU_004414_0_1_1; -.
DR InParanoid; O94258; -.
DR OMA; RFSPLCW; -.
DR PhylomeDB; O94258; -.
DR EvolutionaryTrace; O94258; -.
DR PRO; PR:O94258; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:PomBase.
DR GO; GO:0016363; C:nuclear matrix; ISO:PomBase.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0005525; F:GTP binding; NAS:PomBase.
DR GO; GO:0031267; F:small GTPase binding; ISO:PomBase.
DR GO; GO:0000049; F:tRNA binding; ISO:PomBase.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952; PTHR15952; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Reference proteome; RNA-binding;
KW Transport; tRNA processing; tRNA-binding.
FT CHAIN 1..978
FT /note="Exportin-T"
FT /id="PRO_0000343105"
FT HELIX 2..14
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 20..35
FT /evidence="ECO:0007829|PDB:3IBV"
FT STRAND 36..38
FT /evidence="ECO:0007829|PDB:3ICQ"
FT HELIX 39..46
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 50..52
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 55..71
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 74..76
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 78..94
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 103..119
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 120..123
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 127..138
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 141..158
FT /evidence="ECO:0007829|PDB:3IBV"
FT STRAND 161..163
FT /evidence="ECO:0007829|PDB:3ICQ"
FT HELIX 167..183
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 185..201
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 205..218
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 219..221
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 224..228
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 230..239
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 243..258
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 263..279
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 289..310
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 318..330
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 332..339
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 344..348
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 351..364
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 365..367
FT /evidence="ECO:0007829|PDB:3ICQ"
FT HELIX 372..387
FT /evidence="ECO:0007829|PDB:3IBV"
FT STRAND 393..395
FT /evidence="ECO:0007829|PDB:3ICQ"
FT STRAND 401..404
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 406..426
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 428..446
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 451..467
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 468..471
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 475..477
FT /evidence="ECO:0007829|PDB:3IBV"
FT STRAND 481..483
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 488..498
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 501..503
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 507..519
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 521..525
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 528..530
FT /evidence="ECO:0007829|PDB:3ICQ"
FT HELIX 531..538
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 541..545
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 549..551
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 552..565
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 566..569
FT /evidence="ECO:0007829|PDB:3IBV"
FT STRAND 571..573
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 574..580
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 581..585
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 602..607
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 608..610
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 611..627
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 632..654
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 663..679
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 691..708
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 713..726
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 727..730
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 731..734
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 735..737
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 738..748
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 751..753
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 754..767
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 768..771
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 773..790
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 800..820
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 825..828
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 830..833
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 836..846
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 854..868
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 873..875
FT /evidence="ECO:0007829|PDB:3ICQ"
FT HELIX 879..892
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 893..895
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 908..934
FT /evidence="ECO:0007829|PDB:3IBV"
FT TURN 935..938
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 946..952
FT /evidence="ECO:0007829|PDB:3IBV"
FT HELIX 971..974
FT /evidence="ECO:0007829|PDB:3IBV"
SQ SEQUENCE 978 AA; 110114 MW; 2875E1DBAE818829 CRC64;
MSAQDVENAV EAALDPSVGP IIKQQATDFI GSLRSSSTGW KICHEIFSEK TKYKPSTRLI
CLQTLSEKVR EWNNESNLLE LQMIRDSVWS YIKELSFLDE PAYISNAVQH LLTLLFLQLY
PSNWNDFFAS LQGVIAASSQ SEFSNFYLKV LLSIGDEIAD SLVLKTDVQI QKDNLVKDAI
RANDMSDIVS FVYEMMLAYS NAKNYGTVGL CLQVYAQWVS WININLIVNE PCMNLLYSFL
QIEELRCAAC ETMTEIVNKK MKPLEKLNLL NILNLNLFFS KSQEQSTDPN FDEHVAKLIN
AQGVELVAIK SDPSELSPEL KENCSFQLYN LFPYLIRYLS DDYDETSTAV FPFLSDLLVS
LRKESSSKEL SASLKEFLKS LLEAIIKKMK YDESQEWDDD PDSEEEAEFQ EMRKKLKIFQ
DTINSIDSSL FSSYMYSAIT SSLSTAATLS PENSWQLIEF ALYETYIFGE GLRGPDAFFN
EVDKSPTVLS QILALVTTSQ VCRHPHPLVQ LLYMEILVRY ASFFDYESAA IPALIEYFVG
PRGIHNTNER VRPRAWYLFY RFVKSIKKQV VNYTESSLAM LGDLLNISVS PVTDMDAPVP
TLNSSIRNSD FNSQLYLFET VGVLISSGNL TPEEQALYCD SLINALIGKA NAALSSDLSA
LENIISVYCS LMAIGNFAKG FPARGSEEVA WLASFNKASD EIFLILDRMG FNEDIRGAVR
FTSGRIINVV GPDMLPKVPQ LISILLNSID MNELVDVLSF ISQLIHIYKD NMMEITNRML
PTLLMRIFSS LSAAPQGTDD AVKQNDLRKS YISFILQLLN KGFGSILFTE ENQVYFDPLI
NSILHFANLV GEPATQKSSI ALVSKMVSLW GGKDGIAGFE NFTLSLTPLC FEMPVNPNFN
TRDGQSLVVL GELAGLQKII LEKLGDIYKS YLVTVYFPTV NFPDVMASEY LQALSNLDSR
SFKQFFQKFI QALKSGNV
