ID   XPOT_SCLS1              Reviewed;        1023 AA.
AC   A7EPT5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=los1; ORFNames=SS1G_07334;
OS   Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS   (Whetzelinia sclerotiorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Sclerotinia.
OX   NCBI_TaxID=665079;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18683 / 1980 / Ss-1;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CH476629; EDO04851.1; -; Genomic_DNA.
DR   RefSeq; XP_001591888.1; XM_001591838.1.
DR   AlphaFoldDB; A7EPT5; -.
DR   SMR; A7EPT5; -.
DR   STRING; 665079.A7EPT5; -.
DR   EnsemblFungi; EDO04851; EDO04851; SS1G_07334.
DR   GeneID; 5488030; -.
DR   KEGG; ssl:SS1G_07334; -.
DR   VEuPathDB; FungiDB:sscle_06g049980; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; A7EPT5; -.
DR   OMA; RFSPLCW; -.
DR   Proteomes; UP000001312; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1023
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343106"
SQ   SEQUENCE   1023 AA;  114303 MW;  3E644AFAD0CADE36 CRC64;
     MDAQIEKAIE IAWDPRSDQN LKEQAVQYLT QVRGDSSSLQ ACLNLFTRDP KAAEVVRLVS
     LDIVNNAIQT QHIDDQSLRG LKEQLHDYVR RTYASGNEVD PPALQNKLTQ TLTFLFSSLY
     KEGWESFIRD FLSFTGHQNG TVDNLPGVVL YLRLLSSIHD EIADLMIVRA GGETKRNVEL
     KDLVRARDVQ IVAGSFQHIL TYWQGNNDAI VEMTLKVIGK WVSWIDISLV VNQDILNLLF
     PLVGRNPNGG EDKVKDAAID CFTEIVAKKM KPSDKIGMIL FLNLGEVVSQ LIASPALHDL
     RNTSSYDTDL AEAVAKLVNN VVSDLVKILE DTKVEPEVRA QAEQSLQTFL PLLLRFFSDE
     YDEICATVIP SLTELNTFLR KAQPLPPAYS AMLTPILNAI IQKMRYDDTS SYADEDELTD
     EAEFQELRKR LQVLQKTIAA VDEALYVDVL SNVIGNTFQR LDQQNGQIDW RDLDLALHEM
     YLFGELTLVN GGLYAKSQPS SIAAERLIVM MSKMVESGIA SFNHPAISLQ YMEICVRYCS
     FFENQTQYIP QVLEQFVGFV HHNHSRVRIR SWYLFHRFVK HLRGQVGNVA ETIIQSISDL
     LPLKAEVPKE SDDDMSSEDG SHDAADVAFN AQLNLYEAIG CISSTTSTPI EKQAIYARTI
     MNPLFSDVQR HLEQAKSGNA QAVLQIHHII FALGSLAHGF SDWSPGEGKR AGQAPAKEIT
     IEFSRAAEAI LFALEALKSS SEIRNAARSS FSRLMGVMGV AMLPLLPRWI DGLLTQSSSK
     EEIGMFLRLL DQVVFGFKKD IHEVLNSLLT PLFQRVFASL SEPVTGTDDG IQLAELRREY
     LSFVTVILNN ELGSVLVSEQ NQAFFDPLVQ SVTTLAKTVT NETGNLAASK IAFSVMTKMA
     ELWGGPTIAT PGQPITSSVQ PQPTFPGFDT FLIERFHPVC WEVLREPHFR PMVDAQSKSV
     LNELAGLEHV IYMKTGNMFV EHLQGNFFPS MGVDGSGFIK SMVESPERKG LATFLQNWLK
     GRA