ID   XPOT_VANPO              Reviewed;        1062 AA.
AC   A7TE19;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; ORFNames=Kpol_1018p179;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; DS480378; EDO19639.1; -; Genomic_DNA.
DR   RefSeq; XP_001647497.1; XM_001647447.1.
DR   AlphaFoldDB; A7TE19; -.
DR   SMR; A7TE19; -.
DR   STRING; 436907.A7TE19; -.
DR   EnsemblFungi; EDO19639; EDO19639; Kpol_1018p179.
DR   GeneID; 5548005; -.
DR   KEGG; vpo:Kpol_1018p179; -.
DR   eggNOG; KOG2021; Eukaryota.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; A7TE19; -.
DR   OMA; RFSPLCW; -.
DR   OrthoDB; 142520at2759; -.
DR   PhylomeDB; A7TE19; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1062
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343108"
SQ   SEQUENCE   1062 AA;  119811 MW;  2E93177DDAD61AB6 CRC64;
     MLQRIREVVS LANNPATDAV TKKQALDYLE QMKSDPNAIQ IFCSMLTDSG SDDLCIFVSL
     QILCDLVAMN TSVDLLFVKN SIVEFLRGKI NRNIKDAEFL RNKISELITR LFINMYGEVN
     GNQWNTFYKD LIALLSIDSL LTGPSEHFSP LGLDYFARIC IQINSEVADQ TFLRSKDEQT
     KNNNLKDTMR LEDVQTLVTI WFNCLKSLII QQQNFELAVI ILSCIGAFIS WVDITLIVNP
     EYINIIYGYL DYSDTKIACS QCLCEIISKK MKPVDKLTLL SMLNLTDKVA SIGEDDIDVY
     EKLAKLASSV GLELSIILEQ CNEGVQSNET LEVANAADQQ VLNQVAPLVL KFMSHEYDSV
     TEQCFPFISQ YLAILKKLFA IGGKPGTAVA INSKRQPLDE AHQNFLVSLL NVCFEKMKID
     DSSESNSEEA IEEFNDIVRS KLKVFQDSIA VINPNIYLEN ISNHIQVSLA GTDWTVLELA
     IFQMHNLCES IRNNLFGLNK TEISTSAATQ LMHKFMALLL QNSNLFQMDN RYVQILFFEL
     VVRHYTFLGS DTKDAVSLLN IFCSEFGMFN KSEKVILRTW YLFTRFVKIS KPHLSVSVLS
     QLVSKVMPLL VIKTVTPSVD GSEDCDTTFD SQLYIFEGVG MLIGANADNT YDILDQVLTP
     LFTDLERCIS LQSQSPSIVL QSHHILMAIG TLARGTHMGL VPENQVNNAL VNEKLIHRTL
     IEKFSNIAEV VLVTFSYFNK HETIRDASRF TFARLIPILN GGIVTFASKL VVLFLESDLK
     TMEMNDFLGF LGQMVHTFHG DENFYDLFDN LLTPVINKLH ILLDHLESES NESNWYGEQN
     GRENNGNDVS GARTSKTVVV TDSYRDKILL KKAYYGFLQS FVTNNVTSLL LSNRNRSILP
     TILGDLLSYN PQEIQETSTM KLALNVLVNF IKFFGSGGCT DVNDVHASSI GKLDGLNEYF
     ITRTIPLAFE IPFKPQYKFN INDGSCRVIA CDLSRVLKEM YIQSGGGQDV NSNPALKYLT
     EVYFPQIQLP SELGMELIQM LITQDTKAFE KYYVTLINRL TS