ID   XPOT_YARLI              Reviewed;        1025 AA.
AC   Q6C715;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Exportin-T;
DE   AltName: Full=Exportin(tRNA);
DE   AltName: Full=Karyopherin-beta;
DE   AltName: Full=tRNA exportin;
GN   Name=LOS1; OrderedLocusNames=YALI0E04576g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC       translocation across the nuclear pore complex. Involved in pre-tRNA
CC       splicing, probably by affecting the interaction of pre-tRNA with
CC       splicing endonuclease (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79128.1; -; Genomic_DNA.
DR   RefSeq; XP_503547.1; XM_503547.1.
DR   AlphaFoldDB; Q6C715; -.
DR   SMR; Q6C715; -.
DR   STRING; 4952.CAG79128; -.
DR   PRIDE; Q6C715; -.
DR   EnsemblFungi; CAG79128; CAG79128; YALI0_E04576g.
DR   GeneID; 2912203; -.
DR   KEGG; yli:YALI0E04576g; -.
DR   VEuPathDB; FungiDB:YALI0_E04576g; -.
DR   HOGENOM; CLU_004414_0_1_1; -.
DR   InParanoid; Q6C715; -.
DR   OMA; RFSPLCW; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016363; C:nuclear matrix; IBA:GO_Central.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0071528; P:tRNA re-export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR045546; Exportin-T_C.
DR   InterPro; IPR040017; XPOT.
DR   PANTHER; PTHR15952; PTHR15952; 1.
DR   Pfam; PF19282; Exportin-T; 2.
DR   Pfam; PF08389; Xpo1; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport;
KW   tRNA processing; tRNA-binding.
FT   CHAIN           1..1025
FT                   /note="Exportin-T"
FT                   /id="PRO_0000343109"
SQ   SEQUENCE   1025 AA;  114999 MW;  CED17E8315030CEF CRC64;
     MEDQIEQAVD IAIQGVGDPA VRQQALDFCN QVKASDEGWQ MCLAMFAGDR KRSDAARYFS
     LQVIDEALGR LNREQLVYVR DHLFAYVRMG SGLSQGQANV NVGQAVSFAD DPVHMKNKLG
     ETLAYLFIMT YTEIWDTFFY DFERLLESPE NQFGNPRAAD LYLRVLNDIH REIGDTLIIR
     DPAVQSRNND LKDLIRNRDM ARLADSWKKI LMYYKDQQLE PLATEIVNNA LRVIGGWVSW
     AELTLIAEPE ALEAIFNLLS SPKSRIHACD CLSEIVAKKM YPNAKFQLIQ SLNLTSIIHT
     LSQSADIEFD ERVAKLANSI GSELIHIVET ESQEFSANCE ALLLDMFPLL LRYLGNEYDD
     TSSQVLPSVG SYLQLVRRDS KREKAKINPN RLTKNTADQY ENFPADRTFI SDQRHAVVRS
     ILEAVMKKCR YLDDQEWEED EDGEFCELRQ RLKNLQDMCA SIDNQLFLDD VCPVISQALS
     LPPTADWRDI ELGMFELQTL SEAMRSGALS TVKTGQNESP ATQAFNNLFF QMVASDAVAQ
     CPQPAVHLLF MEIVVKHSSL FSQHNTNLLN RVLEFFVSPL GIQNSESTKV QMRSWILFHK
     FCKSVKPQIG QVAQLLVDSI RPLLVIQTED DTDSDDESAG SAFNAQLNLF ELSGILVSIL
     DEASATNGVE QTLQPIFTAV EKAIGVSPPN AESITLVHHN LVAIGTFAHG LDGSSNKLPD
     GILQLFKNSA EVVNVALDRI PDTKVREAAR TVFTRLVPIL GSSILSEIST LIQILLQRCS
     HAELADFLGF LGHLLHSFRN DEGVYNMLKS LLSPLCQRVF ASLEELSASA DAGNTDDKVL
     KVEIQRAYLM FIMQILRDRM GGAIVEDKQL ADSIIKSVIH YASDPTDIYT CRSAASCLTK
     MIQLWGNGEL EAASAEESVF DQGQKIDGFE QIVLEFSGLC WQVPASSGFN LQDAQSKILV
     TELGNIQKHI YLKKGDQFLS YLVEQYFPQI GVPDNAAKDY VEKLKTLENK DFKKYFSAFV
     NELVK