XRCC2_ARATH
ID XRCC2_ARATH Reviewed; 372 AA.
AC Q682D3; Q8GVF2; Q9FLG6;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 09-NOV-2004, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=DNA repair protein XRCC2 homolog;
DE AltName: Full=X-ray repair cross-complementing protein 2 homolog;
DE Short=AtXRCC2;
GN Name=XRCC2; OrderedLocusNames=At5g64520; ORFNames=T12B11.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Siaud N.;
RT "A study of RAD51 homologues from Arabidopsis.";
RL Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: Involved in the homologous recombination repair (HRR) pathway
CC of double-stranded DNA, thought to repair chromosomal fragmentation,
CC translocations and deletions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=alpha;
CC IsoId=Q682D3-1; Sequence=Displayed;
CC Name=2; Synonyms=beta;
CC IsoId=Q682D3-2; Sequence=VSP_011866, VSP_011867, VSP_011868;
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11419.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ421043; CAD12880.1; -; mRNA.
DR EMBL; AB010076; BAB11419.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97911.1; -; Genomic_DNA.
DR EMBL; AK175434; BAD43197.1; -; mRNA.
DR RefSeq; NP_851268.1; NM_180937.2. [Q682D3-1]
DR AlphaFoldDB; Q682D3; -.
DR BioGRID; 21815; 1.
DR STRING; 3702.AT5G64520.1; -.
DR PaxDb; Q682D3; -.
DR DNASU; 836573; -.
DR EnsemblPlants; AT5G64520.1; AT5G64520.1; AT5G64520. [Q682D3-1]
DR GeneID; 836573; -.
DR Gramene; AT5G64520.1; AT5G64520.1; AT5G64520. [Q682D3-1]
DR KEGG; ath:AT5G64520; -.
DR Araport; AT5G64520; -.
DR TAIR; locus:2174759; AT5G64520.
DR eggNOG; KOG2859; Eukaryota.
DR InParanoid; Q682D3; -.
DR PhylomeDB; Q682D3; -.
DR PRO; PR:Q682D3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q682D3; baseline and differential.
DR Genevisible; Q682D3; AT.
DR GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; IEA:InterPro.
DR GO; GO:0005657; C:replication fork; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:TAIR.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:TAIR.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020588; RecA_ATP-bd.
DR InterPro; IPR030547; XRCC2.
DR PANTHER; PTHR46644; PTHR46644; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA damage; DNA recombination; DNA repair;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..372
FT /note="DNA repair protein XRCC2 homolog"
FT /id="PRO_0000122950"
FT VAR_SEQ 168
FT /note="K -> KYFTVLQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_011866"
FT VAR_SEQ 259..289
FT /note="KVSSNDHFSGNVASKAQQPPFREFMPSSWQA -> SPQTTIFQGMLQVKLSN
FT LHFVNSCLLLGRHL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_011867"
FT VAR_SEQ 290..372
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_011868"
SQ SEQUENCE 372 AA; 42361 MW; 8B3C86FF530ED788 CRC64;
MGDDEARSWI RGDETAKQML SRVLKDRAFL LIPPLHRVPL RAGNVVEITG ASTSAKTQIL
IQAAISCILP KTWNGIHYGG LGKLVLFLDL DCRFDVLRLS QMLKHRLLQA NWLGNGAWWQ
LEESNVKSCK SAEEKTKTVF DEELYASCMK RFLYVRCYDS LELLSSLKTL HYRIQQQEAC
GSQVGVLMID SIGAFHWTDR LSSSLALETH NRKSLSLTNV VETIVQELKK LLLVHSLVVL
ATKGTIYEEK YPANENNRKV SSNDHFSGNV ASKAQQPPFR EFMPSSWQAF VTHKIIIRKS
ADYQSLQTGQ QNLLAYSLEW LQPQLSRIDR FIVDDVRKLT TIKPFYSKLL LIYIVIPASS
SHAVWYCHCL VT
