XRCC3_ARATH
ID XRCC3_ARATH Reviewed; 304 AA.
AC Q9FKM5;
DT 09-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=DNA repair protein XRCC3 homolog;
DE AltName: Full=X-ray repair cross-complementing protein 3 homolog;
DE Short=AtXRCC3;
GN Name=XRCC3; OrderedLocusNames=At5g57450; ORFNames=MUA2.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, TISSUE SPECIFICITY, AND INTERACTION
RP WITH RAD51C.
RC STRAIN=cv. Columbia; TISSUE=Flower bud;
RX PubMed=12139010; DOI=10.1023/a:1016047231597;
RA Osakabe K., Yoshioka T., Ichikawa H., Toki S.;
RT "Molecular cloning and characterization of RAD51-like genes from
RT Arabidopsis thaliana.";
RL Plant Mol. Biol. 50:71-81(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. Columbia;
RA Siaud N.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE.
RA Kim J., Kmiec E.;
RT "Cloning and characterization of the gene encoding DNA repair protein XRCC3
RT from Arabidopsis thaliana.";
RL Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [6]
RP FUNCTION.
RX PubMed=14726957; DOI=10.1038/sj.emboj.7600055;
RA Bleuyard J.-Y., White C.I.;
RT "The Arabidopsis homologue of Xrcc3 plays an essential role in meiosis.";
RL EMBO J. 23:439-449(2004).
CC -!- FUNCTION: Plays essential roles in DNA damage repair in both somatic
CC and meiotic cells. It is important for postsynaptic events following
CC pachytene in meiosis. It is also required for DNA cross-links repair
CC and is involved in double strand breaks (DSBs) repair.
CC {ECO:0000269|PubMed:14726957}.
CC -!- SUBUNIT: Interacts with RAD51C. {ECO:0000269|PubMed:12139010}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in various tissues. More expressed in
CC reproductive tissues than in vegetative tissues, with the highest level
CC in young flower buds. {ECO:0000269|PubMed:12139010}.
CC -!- INDUCTION: By genotoxic stress and by DNA damage.
CC {ECO:0000269|PubMed:12139010}.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily. {ECO:0000305}.
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DR EMBL; AB062455; BAB64342.1; -; mRNA.
DR EMBL; AB073492; BAB70684.1; -; mRNA.
DR EMBL; AJ438908; CAD27641.1; -; mRNA.
DR EMBL; AJ438909; CAD27642.1; -; Genomic_DNA.
DR EMBL; AY032998; AAK54457.1; -; Genomic_DNA.
DR EMBL; AB011482; BAB08781.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96903.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96904.1; -; Genomic_DNA.
DR RefSeq; NP_200554.1; NM_125127.3.
DR RefSeq; NP_851202.1; NM_180871.2.
DR AlphaFoldDB; Q9FKM5; -.
DR SMR; Q9FKM5; -.
DR BioGRID; 21094; 1.
DR STRING; 3702.AT5G57450.1; -.
DR iPTMnet; Q9FKM5; -.
DR PaxDb; Q9FKM5; -.
DR PRIDE; Q9FKM5; -.
DR EnsemblPlants; AT5G57450.1; AT5G57450.1; AT5G57450.
DR EnsemblPlants; AT5G57450.2; AT5G57450.2; AT5G57450.
DR GeneID; 835850; -.
DR Gramene; AT5G57450.1; AT5G57450.1; AT5G57450.
DR Gramene; AT5G57450.2; AT5G57450.2; AT5G57450.
DR KEGG; ath:AT5G57450; -.
DR Araport; AT5G57450; -.
DR TAIR; locus:2174577; AT5G57450.
DR eggNOG; KOG1564; Eukaryota.
DR HOGENOM; CLU_041732_1_0_1; -.
DR InParanoid; Q9FKM5; -.
DR OMA; PCLGLQW; -.
DR OrthoDB; 1341207at2759; -.
DR PhylomeDB; Q9FKM5; -.
DR PRO; PR:Q9FKM5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKM5; baseline and differential.
DR Genevisible; Q9FKM5; AT.
DR GO; GO:0033065; C:Rad51C-XRCC3 complex; IBA:GO_Central.
DR GO; GO:0005657; C:replication fork; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; ISS:TAIR.
DR GO; GO:0006302; P:double-strand break repair; IMP:TAIR.
DR GO; GO:0045003; P:double-strand break repair via synthesis-dependent strand annealing; IDA:TAIR.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:TAIR.
DR GO; GO:0071140; P:resolution of mitotic recombination intermediates; IBA:GO_Central.
DR GO; GO:0090656; P:t-circle formation; IBA:GO_Central.
DR GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR CDD; cd01123; Rad51_DMC1_radA; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
DR InterPro; IPR016467; DNA_recomb/repair_RecA-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR033925; Rad51_DMC1_RadA.
DR InterPro; IPR020588; RecA_ATP-bd.
DR Pfam; PF08423; Rad51; 1.
DR PIRSF; PIRSF005856; Rad51; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50162; RECA_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..304
FT /note="DNA repair protein XRCC3 homolog"
FT /id="PRO_0000122953"
FT BINDING 46..53
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 304 AA; 33732 MW; 9164CE294F4E06A7 CRC64;
MQNGKIKPEN LLRRSPTNRK LTTGCEILDG CLRGGISCDS LTEIVAESGC GKTQLCLQLS
LCTQLPISHG GLNGSSLYLH SEFPFPFRRL HQLSHTFHQS NPSIYANYND NPCDHVFVQN
VHSVDHLFDI MPRIDGFVGN SKTRFPLKLI VLDSVAALFR SEFDNTPSDL KKRSSLFFKI
SGKLKQLASK FDLAIVITNQ VTDLVETSDG LSGLRIGNLR YLYSSGRRVV PSLGLAWANC
VNSRFFISRS DGSIVKDRSE KDENCSSSVS RSAKRRLDIV FSPYLPGSSC EFMITREGIC
AVQA
