XRCC4_DICDI
ID XRCC4_DICDI Reviewed; 454 AA.
AC Q54YJ7;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=DNA repair protein xrcc4;
GN Name=xrcc4; ORFNames=DDB_G0278203;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16112620; DOI=10.1016/j.dnarep.2005.06.008;
RA Block W.D., Lees-Miller S.P.;
RT "Putative homologues of the DNA-dependent protein kinase catalytic subunit
RT (DNA-PKcs) and other components of the non-homologous end joining machinery
RT in Dictyostelium discoideum.";
RL DNA Repair 4:1061-1065(2005).
CC -!- FUNCTION: Involved in DNA non-homologous end joining (NHEJ); required
CC for double-strand break repair and V(D)J recombination. Binds to DNA
CC and to DNA ligase IV (lig4). The lig4-xrcc4 complex is responsible for
CC the NHEJ ligation step, and xrcc4 enhances the joining activity of
CC lig4. Binding of the lig4-xrcc4 complex to DNA ends is dependent on the
CC assembly of the DNA-dependent protein kinase complex DNA-PK to these
CC DNA ends (By similarity). {ECO:0000250|UniProtKB:Q13426}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13426}.
CC -!- SIMILARITY: Belongs to the XRCC4-XLF family. XRCC4 subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68274.1; -; Genomic_DNA.
DR RefSeq; XP_642205.1; XM_637113.1.
DR AlphaFoldDB; Q54YJ7; -.
DR STRING; 44689.DDB0232253; -.
DR PaxDb; Q54YJ7; -.
DR EnsemblProtists; EAL68274; EAL68274; DDB_G0278203.
DR GeneID; 8621412; -.
DR KEGG; ddi:DDB_G0278203; -.
DR dictyBase; DDB_G0278203; xrcc4.
DR eggNOG; ENOG502RYHV; Eukaryota.
DR HOGENOM; CLU_603304_0_0_1; -.
DR InParanoid; Q54YJ7; -.
DR OMA; ASEEYMN; -.
DR Reactome; R-DDI-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-DDI-5693571; Nonhomologous End-Joining (NHEJ).
DR PRO; PR:Q54YJ7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0032807; C:DNA ligase IV complex; IBA:GO_Central.
DR GO; GO:0005958; C:DNA-dependent protein kinase-DNA ligase 4 complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:dictyBase.
DR GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; ISS:dictyBase.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR GO; GO:0051351; P:positive regulation of ligase activity; IBA:GO_Central.
DR GO; GO:0010165; P:response to X-ray; IBA:GO_Central.
DR Gene3D; 1.20.5.370; -; 1.
DR Gene3D; 2.170.210.10; -; 1.
DR InterPro; IPR010585; DNA_repair_prot_XRCC4.
DR InterPro; IPR014751; XRCC4-like_C.
DR InterPro; IPR038051; XRCC4-like_N_sf.
DR InterPro; IPR009089; XRCC4_N_sf.
DR PANTHER; PTHR28559; PTHR28559; 1.
DR Pfam; PF06632; XRCC4; 1.
DR SUPFAM; SSF50809; SSF50809; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA recombination; DNA repair; DNA-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..454
FT /note="DNA repair protein xrcc4"
FT /id="PRO_0000377484"
FT REGION 233..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 52726 MW; 312507A91B3B8591 CRC64;
MNESSVSRFE NITDDSGNTN GGFYYLKCNW QYNSFTIYLT DLTNVWSSNV TTKYIENILK
PQGMSFDQYF QLLKKSLLKQ DQTKREFDYK IDKYKRKNNN NINNNNEDIE FIIIIILSEF
DNINVKSSIP LIKLSNHFTT FQHYFDWLFD KYQSLSLQNQ TLTLQTQSLQ SQFNQSLEQN
KLFQLEKDRI ESNLIEKFII ILNEKKKKIK EYKQPINNLL LEQKSISSSL SNCKCNNNNN
NNNNKSIVNN NKNKSPSKQQ VYTTPKKKKR NYQSNLINID NDDDDDLGNN DNVNNINDEN
DNDNDNDNEE DYKPTFNNST PPLLDLLSND YDSYYNVPTN VRKKFKPTPT LTTTTTTTTT
TTTASIIKTP TKKRNSISPQ KSPHHHRNIN IKKNNNNNNP SSPMKKYNAN GTLIPNNNIN
SLIPITPMKS KSKLFNFNDD DNHDIGASEL LNDL
