XRCC5_DICDI
ID XRCC5_DICDI Reviewed; 796 AA.
AC Q54LY5;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=X-ray repair cross-complementing protein 5;
DE EC=3.6.4.-;
DE AltName: Full=ATP-dependent DNA helicase 2 subunit ku80;
GN Name=ku80; ORFNames=DDB_G0286303;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in non-homologous end joining (NHEJ) DNA double
CC strand break repair. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer of ku70 and ku80. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ku80 family. {ECO:0000305}.
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DR EMBL; AAFI02000085; EAL64327.1; -; Genomic_DNA.
DR RefSeq; XP_637846.1; XM_632754.1.
DR AlphaFoldDB; Q54LY5; -.
DR SMR; Q54LY5; -.
DR STRING; 44689.DDB0232002; -.
DR PaxDb; Q54LY5; -.
DR EnsemblProtists; EAL64327; EAL64327; DDB_G0286303.
DR GeneID; 8625560; -.
DR KEGG; ddi:DDB_G0286303; -.
DR dictyBase; DDB_G0286303; ku80.
DR eggNOG; KOG2326; Eukaryota.
DR HOGENOM; CLU_010975_2_1_1; -.
DR InParanoid; Q54LY5; -.
DR OMA; WAMQYVW; -.
DR PhylomeDB; Q54LY5; -.
DR Reactome; R-DDI-5693571; Nonhomologous End-Joining (NHEJ).
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR PRO; PR:Q54LY5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0000785; C:chromatin; IDA:dictyBase.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; ISS:dictyBase.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IBA:GO_Central.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:dictyBase.
DR GO; GO:0071480; P:cellular response to gamma radiation; IBA:GO_Central.
DR GO; GO:0071481; P:cellular response to X-ray; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IMP:dictyBase.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.25.40.240; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR PIRSF; PIRSF016570; Ku80; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SSF100939; 1.
DR SUPFAM; SSF101420; SSF101420; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA recombination; DNA repair; DNA-binding;
KW Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1..796
FT /note="X-ray repair cross-complementing protein 5"
FT /id="PRO_0000377483"
FT DOMAIN 237..467
FT /note="Ku"
FT REGION 272..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 90938 MW; 026C50F48C73114F CRC64;
MTTTIPLKEA VVVILDIGLG MTSKDSDGTT TTTSSIEDAL RSVTLLYQQK LIYGKKDQLG
LVLIGTKGTK NNLQDDGYQH ITVVSDIEEP SIETLKYLEN LAPGESKGDV IDSLIVAMDM
LIRKTENKKY QKRIFLVTNA RDPINTEDLS IVRDQFKKID VKLNIIGVDF LEEIEENNMD
TSNNNKNKSL KEKNEIFLRE FAESVDGVLV PVKQALEMMS FFRSQSVMTR TSFRGALEIT
PELKIPVWGY LKMKQQLLPS LKKISSIAQQ QIEQQQQQQQ QQNKNKNNED NEDNEEGKPN
ITLDVNQEVS YYSITDPDNE ILKPDLLKGY KYGKSLIPFS KIDEDQLKYS SSKCLKVVGF
TDRKSIPIYY NMGNTEVFVS QPGDKQSEEA LSSFIHALVE TDQVMVVRYV KTMNGSPYLG
YMIPHVKSDY VCLYYNHLPL ADDIRQYQFP PISPKNPLTR KSNIPNAEQL EATQQLIDSM
DLMKSEFDED GDPIQMLKPR FTYNPLLQHF YQCLHHRSLH PNTQIPKLDP IIAEYINPDQ
IIMNKSKQSI KNFADKFPLT KTTVFSKTPA ISGGNTNGTT SNTNNTMIGG VKYHWKDGML
IGEEINLDSY VTDDGSEAKK RKVNDFSEFS LDKLVSGYVT EVGTINPVQN FKDMLNRRDM
DLVDKAITLM KERILQLVND SLRDQYYQKA FECIKELRVG CIRESEAEQF NGFLKDMRSL
FQSKKRDDFW QYITADVTSI LGEKSINLIT QDECDSSEVT QEELDQFLDK KVKQFNPPPI
TNVNTDSVDD LFDQIE
