ID   XRE_BACSU               Reviewed;         113 AA.
AC   P23789;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=HTH-type transcriptional regulator Xre;
DE   AltName: Full=Putative PBSX repressor;
GN   Name=xre; OrderedLocusNames=BSU12510;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=2125016; DOI=10.1016/0378-1119(90)90344-q;
RA   Wood H.E., Devine K.M., McConnell D.J.;
RT   "Characterisation of a repressor gene (xre) and a temperature-sensitive
RT   allele from the Bacillus subtilis prophage, PBSX.";
RL   Gene 96:83-88(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / SO113;
RX   PubMed=8083174; DOI=10.1128/jb.176.18.5820-5830.1994;
RA   McDonnell G.E., Wood H., Devine K.M., McConnell D.J.;
RT   "Genetic control of bacterial suicide: regulation of the induction of PBSX
RT   in Bacillus subtilis.";
RL   J. Bacteriol. 176:5820-5830(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Krogh S., O'Reilly M., Nolan N., Devine K.M.;
RL   Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [5]
RP   FUNCTION, AND DNA-BINDING.
RC   STRAIN=168 / SO113;
RX   PubMed=8083175; DOI=10.1128/jb.176.18.5831-5834.1994;
RA   McDonnell G.E., McConnell D.J.;
RT   "Overproduction, isolation, and DNA-binding characteristics of Xre, the
RT   repressor protein from the Bacillus subtilis defective prophage PBSX.";
RL   J. Bacteriol. 176:5831-5834(1994).
CC   -!- FUNCTION: Repressor of PBSX. Binds to four sites close to its own gene.
CC       Necessary for the maintenance of the lysogenic state.
CC       {ECO:0000269|PubMed:2125016, ECO:0000269|PubMed:8083175}.
CC   -!- MISCELLANEOUS: The defective prophage of Bacillus subtilis 168, PBSX,
CC       is a chromosomally based element which encodes a non-infectious phage-
CC       like particle with bactericidal activity. PBSX is induced by agents
CC       which elicit the SOS response (PubMed:2125016).
CC       {ECO:0000305|PubMed:2125016}.
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DR   EMBL; M36478; AAA22894.1; -; Genomic_DNA.
DR   EMBL; M36477; AAA22893.1; -; Genomic_DNA.
DR   EMBL; Z34287; CAA84042.1; -; Genomic_DNA.
DR   EMBL; Z70177; CAA94052.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13108.1; -; Genomic_DNA.
DR   PIR; JQ0810; JQ0810.
DR   RefSeq; NP_389133.1; NC_000964.3.
DR   RefSeq; WP_003232719.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; P23789; -.
DR   SMR; P23789; -.
DR   STRING; 224308.BSU12510; -.
DR   PaxDb; P23789; -.
DR   PRIDE; P23789; -.
DR   EnsemblBacteria; CAB13108; CAB13108; BSU_12510.
DR   GeneID; 936473; -.
DR   KEGG; bsu:BSU12510; -.
DR   PATRIC; fig|224308.179.peg.1352; -.
DR   eggNOG; COG1396; Bacteria.
DR   InParanoid; P23789; -.
DR   OMA; MPGINIL; -.
DR   PhylomeDB; P23789; -.
DR   BioCyc; BSUB:BSU12510-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..113
FT                   /note="HTH-type transcriptional regulator Xre"
FT                   /id="PRO_0000149746"
FT   DOMAIN          6..58
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        15..34
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   VARIANT         4
FT                   /note="G -> S (in temperature-sensitive allele)"
FT   VARIANT         19
FT                   /note="A -> V (in temperature-sensitive allele)"
FT   VARIANT         78
FT                   /note="L -> V (in temperature-sensitive allele)"
SQ   SEQUENCE   113 AA;  13258 MW;  23AF5C9DE3D2B31A CRC64;
     MIGGRLKSLR GKRTQEEIAS HIGVSRARYS HYENGRSEPD YDTLQKLADY FQVTTDYLLT
     GKDKKSDDDM FSDPDLQLAY RDMQDFSPES KQQAIEFINY LKEKEKNRKP KNK