ID   XRE_PHOLL               Reviewed;         148 AA.
AC   Q7N4I0;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Antitoxin Xre {ECO:0000305|PubMed:30315706};
GN   Name=xre {ECO:0000303|PubMed:30315706}; OrderedLocusNames=plu2357;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
RN   [2]
RP   FUNCTION AS AN ANTITOXIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=30315706; DOI=10.1111/mmi.14150;
RA   Skjerning R.B., Senissar M., Winther K.S., Gerdes K., Brodersen D.E.;
RT   "The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell
RT   stasis by degrading NAD+.";
RL   Mol. Microbiol. 111:221-236(2019).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the NAD(+) depleting activity of cognate toxin Res.
CC       {ECO:0000269|PubMed:30315706}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with cognate toxin Rse.
CC       {ECO:0000250|UniProtKB:Q88K58}.
CC   -!- SIMILARITY: Belongs to the MbcA/ParS/Xre antitoxin family.
CC       {ECO:0000305}.
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DR   EMBL; BX571866; CAE14650.1; -; Genomic_DNA.
DR   RefSeq; WP_011146593.1; NC_005126.1.
DR   AlphaFoldDB; Q7N4I0; -.
DR   SMR; Q7N4I0; -.
DR   STRING; 243265.plu2357; -.
DR   EnsemblBacteria; CAE14650; CAE14650; plu2357.
DR   GeneID; 24166293; -.
DR   KEGG; plu:plu2357; -.
DR   eggNOG; COG5642; Bacteria.
DR   HOGENOM; CLU_109353_3_0_6; -.
DR   OMA; WLANPVY; -.
DR   OrthoDB; 1850771at2; -.
DR   BioCyc; PLUM243265:PLU_RS11715-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   InterPro; IPR011979; Antitox_Xre.
DR   InterPro; IPR024467; Xre/MbcA/ParS-like_toxin-bd.
DR   Pfam; PF09722; DUF2384; 1.
DR   TIGRFAMs; TIGR02293; TAS_TIGR02293; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..148
FT                   /note="Antitoxin Xre"
FT                   /id="PRO_0000448601"
SQ   SEQUENCE   148 AA;  16467 MW;  BFB2B319CF87819D CRC64;
     MRVFTPSHKV QSNPLWRTVG FPSSSGPHLN AILNEGLPVT IVDKIQNWST FGKGDILRIA
     GIQIRSYSRR CSGKGKFTAD ESQRIARFVR VMDHAVDLFN GDKDKAAQWM KRPIRGLGYV
     TPESMLDTES GALDVMNLIG RIEHGIVS