ID   XRE_YERE8               Reviewed;         148 AA.
AC   A1JNG6;
DT   13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Antitoxin Xre {ECO:0000303|PubMed:30315706};
GN   Name=xre {ECO:0000303|PubMed:30315706}; OrderedLocusNames=YE2115;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
RN   [2]
RP   FUNCTION AS AN ANTITOXIN, AND EXPRESSION IN E.COLI.
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=30315706; DOI=10.1111/mmi.14150;
RA   Skjerning R.B., Senissar M., Winther K.S., Gerdes K., Brodersen D.E.;
RT   "The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell
RT   stasis by degrading NAD+.";
RL   Mol. Microbiol. 111:221-236(2019).
CC   -!- FUNCTION: Antitoxin component of a type II toxin-antitoxin (TA) system.
CC       Neutralizes the activity of cognate toxin Res.
CC       {ECO:0000269|PubMed:30315706}.
CC   -!- SUBUNIT: Homodimer. Forms a complex with cognate toxin Rse.
CC       {ECO:0000250|UniProtKB:Q88K58}.
CC   -!- SIMILARITY: Belongs to the MbcA/ParS/Xre antitoxin family.
CC       {ECO:0000305}.
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DR   EMBL; AM286415; CAL12185.1; -; Genomic_DNA.
DR   RefSeq; WP_005169556.1; NC_008800.1.
DR   RefSeq; YP_001006355.1; NC_008800.1.
DR   AlphaFoldDB; A1JNG6; -.
DR   SMR; A1JNG6; -.
DR   STRING; 393305.YE2115; -.
DR   EnsemblBacteria; CAL12185; CAL12185; YE2115.
DR   KEGG; yen:YE2115; -.
DR   PATRIC; fig|393305.7.peg.2277; -.
DR   eggNOG; COG5642; Bacteria.
DR   HOGENOM; CLU_109353_3_0_6; -.
DR   OMA; WLANPVY; -.
DR   BioCyc; YENT393305:G13HL-2050-MON; -.
DR   Proteomes; UP000000642; Chromosome.
DR   InterPro; IPR011979; Antitox_Xre.
DR   InterPro; IPR024467; Xre/MbcA/ParS-like_toxin-bd.
DR   Pfam; PF09722; DUF2384; 1.
DR   TIGRFAMs; TIGR02293; TAS_TIGR02293; 1.
PE   1: Evidence at protein level;
KW   Toxin-antitoxin system.
FT   CHAIN           1..148
FT                   /note="Antitoxin Xre"
FT                   /id="PRO_0000448603"
SQ   SEQUENCE   148 AA;  16337 MW;  27B61E790B64B72F CRC64;
     MRAYHPTPAT KTRALWREIG LPASRGTVLV DSIKMGFSVD VIDSIHLWAS IPKAEILRAT
     GIPSRSLTRR RTHDGRFTPE ESERIARFVR VMDAAVDLFG GDKGKAITWM STPIKGLGHR
     SPDSLLETET GALEVCDLIG RLEHGVFS