XRI1_ARATH
ID XRI1_ARATH Reviewed; 300 AA.
AC Q6NLW5; Q9FKC4;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein XRI1;
DE AltName: Full=Protein X-RAY INDUCED 1;
GN Name=XRI1; OrderedLocusNames=At5g48720; ORFNames=K24G6.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INDUCTION BY X-RAYS,
RP SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND INTERACTION WITH MIP1.
RX PubMed=19187040; DOI=10.1111/j.1365-313x.2009.03814.x;
RA Dean P.J., Siwiec T., Waterworth W.M., Schloegelhofer P., Armstrong S.J.,
RA West C.E.;
RT "A novel ATM dependant X-ray inducible gene is essential for both plant
RT meiosis and gametogenesis.";
RL Plant J. 58:791-802(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION BY BLEOMYCIN.
RX PubMed=15506937; DOI=10.1042/bst0320964;
RA West C.E., Waterworth W.M., Sunderland P.A., Bray C.M.;
RT "Arabidopsis DNA double-strand break repair pathways.";
RL Biochem. Soc. Trans. 32:964-966(2004).
CC -!- FUNCTION: Required for mitotic division of the generative cell nucleus
CC and the development of mature tricellular pollen grains, and for male
CC and female meiosis. {ECO:0000269|PubMed:19187040}.
CC -!- SUBUNIT: Interacts (via C-terminal domain) with MIP1.
CC {ECO:0000269|PubMed:19187040}.
CC -!- INTERACTION:
CC Q6NLW5; Q8RX22: MIP1; NbExp=2; IntAct=EBI-2270660, EBI-2270543;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19187040}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NLW5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NLW5-2; Sequence=VSP_037542;
CC -!- INDUCTION: By X-rays and bleomycin treatment.
CC {ECO:0000269|PubMed:15506937, ECO:0000269|PubMed:19187040}.
CC -!- DISRUPTION PHENOTYPE: Complete sterility.
CC {ECO:0000269|PubMed:19187040}.
CC -!- MISCELLANEOUS: The induction by X-rays is dependent on DNA damage
CC signaling by ATM.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB012242; BAB09425.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95715.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95716.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68399.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68400.1; -; Genomic_DNA.
DR EMBL; BT012214; AAS76701.1; -; mRNA.
DR EMBL; BT020567; AAW78586.1; -; mRNA.
DR RefSeq; NP_001154770.1; NM_001161298.2. [Q6NLW5-1]
DR RefSeq; NP_001330159.1; NM_001344803.1. [Q6NLW5-2]
DR RefSeq; NP_001330160.1; NM_001344804.1. [Q6NLW5-1]
DR RefSeq; NP_199683.2; NM_124249.3. [Q6NLW5-2]
DR AlphaFoldDB; Q6NLW5; -.
DR BioGRID; 20176; 1.
DR IntAct; Q6NLW5; 1.
DR STRING; 3702.AT5G48720.2; -.
DR PaxDb; Q6NLW5; -.
DR PRIDE; Q6NLW5; -.
DR ProteomicsDB; 242797; -. [Q6NLW5-1]
DR EnsemblPlants; AT5G48720.1; AT5G48720.1; AT5G48720. [Q6NLW5-2]
DR EnsemblPlants; AT5G48720.2; AT5G48720.2; AT5G48720. [Q6NLW5-1]
DR EnsemblPlants; AT5G48720.3; AT5G48720.3; AT5G48720. [Q6NLW5-2]
DR EnsemblPlants; AT5G48720.4; AT5G48720.4; AT5G48720. [Q6NLW5-1]
DR GeneID; 834930; -.
DR Gramene; AT5G48720.1; AT5G48720.1; AT5G48720. [Q6NLW5-2]
DR Gramene; AT5G48720.2; AT5G48720.2; AT5G48720. [Q6NLW5-1]
DR Gramene; AT5G48720.3; AT5G48720.3; AT5G48720. [Q6NLW5-2]
DR Gramene; AT5G48720.4; AT5G48720.4; AT5G48720. [Q6NLW5-1]
DR KEGG; ath:AT5G48720; -.
DR Araport; AT5G48720; -.
DR TAIR; locus:2156519; AT5G48720.
DR eggNOG; ENOG502QTT2; Eukaryota.
DR InParanoid; Q6NLW5; -.
DR OMA; CTDIDFQ; -.
DR PhylomeDB; Q6NLW5; -.
DR PRO; PR:Q6NLW5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q6NLW5; baseline and differential.
DR Genevisible; Q6NLW5; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0006281; P:DNA repair; IMP:TAIR.
DR GO; GO:0007143; P:female meiotic nuclear division; IMP:TAIR.
DR GO; GO:0007140; P:male meiotic nuclear division; IMP:TAIR.
DR GO; GO:0009555; P:pollen development; IMP:TAIR.
DR GO; GO:0010165; P:response to X-ray; IEP:TAIR.
DR InterPro; IPR039933; XRI1.
DR PANTHER; PTHR33385; PTHR33385; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Meiosis; Nucleus; Reference proteome.
FT CHAIN 1..300
FT /note="Protein XRI1"
FT /id="PRO_0000378327"
FT VAR_SEQ 1..34
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_037542"
SQ SEQUENCE 300 AA; 33719 MW; 23B32F668BDB6FEA CRC64;
MDYGDDDRSS SWNWQVDNYN HQPQSHFSDV PDCTMTEVTL NQEDHSYMFD DENTPVKACS
ELGYHVTTED TNRKMEVHSE TRSALKRRRM LQFEDQPETS LFSSESFSAI LKSSARDDTF
DELLPEGSQL IEGFSEDASA SSFEGLDLYA EEWYADCLND AETPMLPDDL NFGSPDVQVD
ISEYLNVPPE TETREVQRPV TRSSPNVIFK GRKSFSRPVS KLPSSIIYPF AFIKPCGVHG
GMTLKDINQK IRNPPAKPKA HIEEPAVIQT SAFSGKPVVG KTKIRTEGGK GSITIMRTRG
